(E)-S-phenyl 3-((2R,3S,4R,5R)-3,4-bis(tert-butyldimethylsilyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)-tetrahydrofuran-2-yl)prop-2-enethioate

Base Information

Chemical Name:(E)-S-phenyl 3-((2R,3S,4R,5R)-3,4-bis(tert-butyldimethylsilyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)-tetrahydrofuran-2-yl)prop-2-enethioate
CAS No.:911826-87-4
Molecular Formula:C₂₉H₄₄N₂O₆SSi₂
Molecular Weight:604.915
Hs Code.:

(E)-S-phenyl 3-((2R,3S,4R,5R)-3,4-bis(tert-butyldimethylsilyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)-tetrahydrofuran-2-yl)prop-2-enethioate

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Chemical Property of (E)-S-phenyl 3-((2R,3S,4R,5R)-3,4-bis(tert-butyldimethylsilyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)-tetrahydrofuran-2-yl)prop-2-enethioate

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Technology Process of (E)-S-phenyl 3-((2R,3S,4R,5R)-3,4-bis(tert-butyldimethylsilyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)-tetrahydrofuran-2-yl)prop-2-enethioate

There total 2 articles about (E)-S-phenyl 3-((2R,3S,4R,5R)-3,4-bis(tert-butyldimethylsilyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)-tetrahydrofuran-2-yl)prop-2-enethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87418-87-9,69504-12-7
2',3'-bis-O-(tert-butyldimethylsilyl)uridine

: 911826-87-4
(E)-S-phenyl 3-((2R,3S,4R,5R)-3,4-bis(tert-butyldimethylsilyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)-tetrahydrofuran-2-yl)prop-2-enethioate

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin reagent / CH₂Cl₂ / 1.25 h / 0 - 20 °C

2: 477 mg / toluene / 48 h / 20 °C

With Dess-Martin periodane; In dichloromethane; toluene; 2: Wittig reaction;
DOI:10.1021/jm060471h