2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-3-methyl-pent-4-enoylamino)-propionylamino]-3-methyl-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester

Base Information

Chemical Name:2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-3-methyl-pent-4-enoylamino)-propionylamino]-3-methyl-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester
CAS No.:936116-89-1
Molecular Formula:C₅₄H₆₉N₇O₁₀
Molecular Weight:976.183
Hs Code.:

2-[2-(2-{2-[2-(2-<i>tert</i>-butoxycarbonylamino-3-methyl-pent-4-enoylamino)-propionylamino]-3-methyl-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester

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Chemical Property of 2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-3-methyl-pent-4-enoylamino)-propionylamino]-3-methyl-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester

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Technology Process of 2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-3-methyl-pent-4-enoylamino)-propionylamino]-3-methyl-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester

There total 1 articles about 2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-3-methyl-pent-4-enoylamino)-propionylamino]-3-methyl-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: Fmoc-Asn(Trt)-OSu

: 2-azido-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 2-tert-butoxycarbonylamino-3-methyl-pent-4-enoic acid

: 146549-21-5
2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid

: 936116-89-1
2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-3-methyl-pent-4-enoylamino)-propionylamino]-3-methyl-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester

Guidance literature:: Multistep reaction;
DOI:10.1039/b618085j

Reference yield:

: 936116-89-1
2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-3-methyl-pent-4-enoylamino)-propionylamino]-3-methyl-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester

: 7-tert-butoxycarbonylamino-4,8,22-trimethyl-3,6,13,16,23-pentaoxo-15-[(trityl-carbamoyl)-methyl]-2,5,14,17,24-pentaaza-bicyclo[10.10.2]tetracosa-9,20-diene-18-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2nd generation Grubbs' catalyst / CH₂Cl₂ / 2 h

2: 2nd generation Grubbs' catalyst / CH₂Cl₂ / 24 h

tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane;
DOI:10.1039/b618085j

Reference yield:

: 936116-89-1
2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-3-methyl-pent-4-enoylamino)-propionylamino]-3-methyl-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester

: 10-{2-[2-(2-tert-butoxycarbonylamino-3-methyl-pent-4-enoylamino)-propionylamino]-3-methyl-pent-4-enoylamino}-3,11-dioxo-2-[(trityl-carbamoyl)-methyl]-1,4diaza-cycloundec-7-ene-5-carboxylic acid methyl ester

: 936116-73-3
2-allyl-13-[2-(2-tert-butoxycarbonylamino-3-methyl-pent-4-enoylamino)-propionylamino]-12-methyl-3,6,14-trioxo-5-[(trityl-carbamoyl)-methyl]-1,4,7triaza-cyclotetradec-10-ene-8-carboxylic acid methyl ester

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 2h;
DOI:10.1039/b618085j