phosphonic acid diethyl ester

Base Information

• Chemical Name: phosphonic acid diethyl ester
• CAS No.: 135789-87-6
• Molecular Formula: C₁₁H₁₆FO₅PS
• Molecular Weight: 310.283
• Mol file: 135789-87-6.mol

Synonyms:

Chemical Property of phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phosphonic acid diethyl ester

There total 7 articles about phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

diethyl phenylsulfonylmethylphosphonate (56069-39-7) → phosphonic acid diethyl ester (135789-87-6,114968-97-7)

Guidance literature:

With Selectfluor; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at -78 - 0 ℃;

DOI:10.1021/jo051980e

Reference yield: 73.0%

fluoromethyl phenyl sulfone (20808-12-2) + diethyl chlorophosphate (814-49-3) → phosphonic acid diethyl ester (135789-87-6,114968-97-7)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -70 ℃; for 1.5h;

DOI:10.1080/00397919508015493

Reference yield: 61.0%

C11H16KO5PS → phosphonic acid diethyl ester (135789-87-6,114968-97-7)

Guidance literature:

With Selectfluor; In N,N-dimethyl-formamide; tert-butyl alcohol; for 0.166667h; Ambient temperature;

DOI:10.1021/jo00062a023

upstream raw materials:

diethyl phenylsulfonylmethylphosphonate

fluoromethyl phenyl sulfone

diethyl chlorophosphate

diethyl [(phenylthio)methyl]phosphonate

Downstream raw materials:

(1-fluoro-1-phenylsulfonyl-ethylidene)cyclohexane

1-((Z)-2-Benzenesulfonyl-2-fluoro-vinyl)-4-nitro-benzene

1-(2-benzenesulfonyl-2-fluoro-vinyl)-4-nitrobenzene

(Z)-1-fluoro-1-phenylsulfonyl-pent-1-ene