4-Quinolinepropanoic acid, a-amino-, (S)-

Base Information

• Chemical Name: 4-Quinolinepropanoic acid, a-amino-, (S)-
• CAS No.: 137855-78-8
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.23600
• Mol file: 137855-78-8.mol

Synonyms:L-3-(4-quinolyl)-alanine;

Chemical Property of 4-Quinolinepropanoic acid, a-amino-, (S)-

Chemical Property:

• PSA: 76.21000
• LogP: 1.88950

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Quinolinepropanoic acid, a-amino-, (S)-

There total 3 articles about 4-Quinolinepropanoic acid, a-amino-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(quinolin-4-yl)acrylic acid (81124-52-9) → (S)-2-amino-3-(quinolin-4-yl)propanoic acid (137855-78-8)

Guidance literature:

With phenylalanine ammonia lyase from Anabaena variabilis; ammonium carbamate; In water; at 37 ℃; for 22h; pH=9; Enzymatic reaction;

DOI:10.1021/acs.orglett.6b02559

Reference yield:

quinoline-4-carboxaldehyde (4363-93-3) → (S)-2-amino-3-(quinolin-4-yl)propanoic acid (137855-78-8)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / dimethyl sulfoxide / 16 h / 100 °C

2: ammonium carbamate; phenylalanine ammonia lyase from Anabaena variabilis / water / 22 h / 37 °C / pH 9 / Enzymatic reaction

With piperidine; phenylalanine ammonia lyase from Anabaena variabilis; ammonium carbamate; In water; dimethyl sulfoxide;

DOI:10.1021/acs.orglett.6b02559

Reference yield:

→ (S)-2-amino-3-(quinolin-4-yl)propanoic acid (137855-78-8)

Guidance literature:

upstream raw materials:

(E)-3-(quinolin-4-yl)acrylic acid

quinoline-4-carboxaldehyde

Refernces

• 1、 -. "GADD45BETA TARGETING AGENTS". . . Retrieved 2012/11/08.