Technology Process of NEt-4IP
There total 7 articles about NEt-4IP which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 6-[ethyl(4-isopropoxy-3-isopropylphenyl)amino]pyridine-3-carboxylate;
With
sodium hydroxide;
In
methanol;
With
hydrogenchloride;
In
water;
DOI:10.1021/jm501863r
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: nitric acid; zinc(II) chloride / ethyl acetate / 0.8 h / Sonication; Cooling with ice
2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere
3.1: hydrogen; palladium 10% on activated carbon / methanol / 5.5 h / 20 °C
4.1: methanesulfonic acid / 1,4-dioxane / 17 h / 120 °C / Inert atmosphere
5.1: sulfuric acid / 5.58 h / 80 °C / Inert atmosphere
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 20 °C / Inert atmosphere
6.2: 0.3 h / 20 °C
7.1: sodium hydroxide / methanol
With
methanesulfonic acid; sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; sodium hydride; potassium carbonate; potassium iodide; sodium hydroxide; zinc(II) chloride;
In
1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm501863r
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide
2: sodium hydroxide / methanol
With
potassium carbonate; potassium iodide; sodium hydroxide;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm501863r
![methyl 6-[ethyl(4-isopropoxy-3-isopropylphenyl)amino]pyridine-3-carboxylate](/Databaselist/images/loading.webp)
