N-benzylamino(ferrocenyl)methane phosphonous acid

Base Information

• Chemical Name: N-benzylamino(ferrocenyl)methane phosphonous acid
• CAS No.: 712349-28-5
• Molecular Formula: C₁₈H₂₀FeNO₂P
• Molecular Weight: 369.183
• Mol file: 712349-28-5.mol

Synonyms:

Chemical Property of N-benzylamino(ferrocenyl)methane phosphonous acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-benzylamino(ferrocenyl)methane phosphonous acid

There total 1 articles about N-benzylamino(ferrocenyl)methane phosphonous acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

[(η(5)-C5H5)Fe(η(5)-C5H4-C(H)=N-CH2-C6H5)] + hypophosphorous acid (6303-21-5) → N-benzylamino(ferrocenyl)methane phosphonous acid (712349-28-5)

Guidance literature:

In acetonitrile; Fe complex dissolved in MeCN; H3PO2 (1 equiv.) added; refluxed for 1 h; stirred at room temp. for 3 d; filtered; ppt. washed with cold water; elem. anal.;

DOI:10.1016/j.jorganchem.2004.02.025

Reference yield: 25.0%

N-benzylamino(ferrocenyl)methane phosphonous acid (712349-28-5) + 2',3'-isopropylidene adenosine (362-75-4) → N',N''-dicyclohexyl-N-benzyl-guanidyno(ferrocenyl)methanephosphonous acid (712349-47-8) + O,O'-iso-propylideneadenosinyl N-benzylamino(ferrocenyl)methane phosphonite

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; isopropylideneadenosine and dicyclohexylcarbodiimide added to suspn. of Fe complex (molar ratio 1:1:1) in CH2Cl2; refluxed for 10 h with stirring; stirred at room temp. overnight; repeated during 7 d; phosphonous acid and ester (3:1) obtained; filtered; ppt. washed with CH2Cl2 and discarded; filtrate evapd.; dissolved in CH2Cl2; shaken with charcoal; filtered; chromd. (cellulose powder); evapd.; elem. anal.; mixt. of four diastereoisomers (1:1:1:1) of ester obtained;

DOI:10.1016/j.jorganchem.2004.02.025

Reference yield:

N-benzylamino(ferrocenyl)methane phosphonous acid (712349-28-5) + N,N'-di-cyclohexylformamidine (2303-89-1) → N',N''-dicyclohexyl-N-benzyl-guanidyno(ferrocenyl)methanephosphonous acid (712349-47-8)

Guidance literature:

In dichloromethane; dicyclohexylcarbodiimide added to suspn. of Fe complex (molar ratio 1:1)in CH2Cl2; refluxed for 10 h with stirring; stirred at room temp. overn ight; repeated during 7 d; filtered through cellulose powder; evapd.;

DOI:10.1016/j.jorganchem.2004.02.025

upstream raw materials:

hypophosphorous acid

Downstream raw materials:

N',N''-dicyclohexyl-N-benzyl-guanidyno(ferrocenyl)methanephosphonous acid