(E)-(2R,3R,6S,7S)-3-Hydroxy-2,4,6-trimethyl-7-triethylsilanyloxy-oct-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

Base Information

Chemical Name:(E)-(2R,3R,6S,7S)-3-Hydroxy-2,4,6-trimethyl-7-triethylsilanyloxy-oct-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester
CAS No.:205691-95-8
Molecular Formula:C₄₁H₆₃NO₆SSi
Molecular Weight:726.106
Hs Code.:

(E)-(2R,3R,6S,7S)-3-Hydroxy-2,4,6-trimethyl-7-triethylsilanyloxy-oct-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

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Chemical Property of (E)-(2R,3R,6S,7S)-3-Hydroxy-2,4,6-trimethyl-7-triethylsilanyloxy-oct-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

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Technology Process of (E)-(2R,3R,6S,7S)-3-Hydroxy-2,4,6-trimethyl-7-triethylsilanyloxy-oct-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

There total 4 articles about (E)-(2R,3R,6S,7S)-3-Hydroxy-2,4,6-trimethyl-7-triethylsilanyloxy-oct-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 299-42-3,7009-81-6,90-83-5,6912-63-6
ephedrine

: 205691-95-8
(E)-(2R,3R,6S,7S)-3-Hydroxy-2,4,6-trimethyl-7-triethylsilanyloxy-oct-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 96 percent / pyridine / CH₂Cl₂

3: 1.) n-Bu₂BOTf, i-Pr₂NEt / 1.) CH₂Cl₂, -78 deg C, 2 h, 2.) CH₂Cl₂, -78 deg C

With pyridine; di-n-butylboryl trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0040-4039(98)00123-3

Reference yield:

: 130881-18-4
1,2,3,4,5,6,7,8-octahydro-9-anthracenesulfonyl chloride

: 205691-95-8
(E)-(2R,3R,6S,7S)-3-Hydroxy-2,4,6-trimethyl-7-triethylsilanyloxy-oct-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 96 percent / pyridine / CH₂Cl₂

3: 1.) n-Bu₂BOTf, i-Pr₂NEt / 1.) CH₂Cl₂, -78 deg C, 2 h, 2.) CH₂Cl₂, -78 deg C

With pyridine; di-n-butylboryl trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0040-4039(98)00123-3

Reference yield:

: 205691-91-4
(1R,2S)-2-(N-methyl-N-(1,2,3,4,5,6,7,8-octahydro-9-anthracenesulfonyl))amino-1-phenyl-1-propanol

: 205691-95-8
(E)-(2R,3R,6S,7S)-3-Hydroxy-2,4,6-trimethyl-7-triethylsilanyloxy-oct-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / pyridine / CH₂Cl₂

2: 1.) n-Bu₂BOTf, i-Pr₂NEt / 1.) CH₂Cl₂, -78 deg C, 2 h, 2.) CH₂Cl₂, -78 deg C

With pyridine; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0040-4039(98)00123-3