methyl ((S)-1-(2-(2-((3R,4R)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:methyl ((S)-1-(2-(2-((3R,4R)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate
CAS No.:1365541-63-4
Molecular Formula:C₄₂H₄₉N₅O₆
Molecular Weight:719.881
Hs Code.:

methyl ((S)-1-(2-(2-((3R,4R)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Chemical Property of methyl ((S)-1-(2-(2-((3R,4R)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Technology Process of methyl ((S)-1-(2-(2-((3R,4R)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

There total 13 articles about methyl ((S)-1-(2-(2-((3R,4R)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₄H₇₇N₅O₆Si₂

: 1365541-63-4
methyl ((S)-1-(2-(2-((3R,4R)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm201620t

Reference yield:

: 1365541-31-6
(3S,4R)-3-allyl-3-benzyl-4-hydroxydihydrofuran-2(3H)-one

: 1365541-63-4
methyl ((S)-1-(2-(2-((3R,4R)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-butyl-3-methylimidazolium Tetrafluoroborate / 1,4-dioxane / 0.58 h / 180 °C / Microwave irradiation

2.1: 2,6-dimethylpyridine; triethylamine / 1,4-dioxane / 0 - 25 °C

3.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water / 20 °C

4.1: acetic acid / tetrahydrofuran / 20 °C

4.2: 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; tetrabutyl ammonium fluoride; acetic acid; triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jm201620t

Reference yield:

: C₁₄H₁₄O₃

: 1365541-63-4
methyl ((S)-1-(2-(2-((3R,4R)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol; sodium tetrahydroborate / tetrahydrofuran / 2 h / 20 °C

2.1: 1-butyl-3-methylimidazolium Tetrafluoroborate / 1,4-dioxane / 0.58 h / 180 °C / Microwave irradiation

3.1: 2,6-dimethylpyridine; triethylamine / 1,4-dioxane / 0 - 25 °C

4.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water / 20 °C

5.1: acetic acid / tetrahydrofuran / 20 °C

5.2: 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With 2,6-dimethylpyridine; methanol; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; tetrabutyl ammonium fluoride; acetic acid; triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jm201620t