(4R,4aS,6R,7R,7aR,12bS)-6-(2-(benzyloxy)propan-2-yl)-3-(cyclopropylmethyl)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline hydrochloride

Base Information

Chemical Name:(4R,4aS,6R,7R,7aR,12bS)-6-(2-(benzyloxy)propan-2-yl)-3-(cyclopropylmethyl)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline hydrochloride
CAS No.:1367596-81-3
Molecular Formula:C₃₄H₄₃NO₄*ClH
Molecular Weight:566.181
Hs Code.:

(4R,4aS,6R,7R,7aR,12bS)-6-(2-(benzyloxy)propan-2-yl)-3-(cyclopropylmethyl)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline hydrochloride

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Chemical Property of (4R,4aS,6R,7R,7aR,12bS)-6-(2-(benzyloxy)propan-2-yl)-3-(cyclopropylmethyl)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline hydrochloride

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Technology Process of (4R,4aS,6R,7R,7aR,12bS)-6-(2-(benzyloxy)propan-2-yl)-3-(cyclopropylmethyl)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline hydrochloride

There total 5 articles about (4R,4aS,6R,7R,7aR,12bS)-6-(2-(benzyloxy)propan-2-yl)-3-(cyclopropylmethyl)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5083-80-7
N-(cyclopropylmethyl)northebaine

: 1367596-81-3
(4R,4aS,6R,7R,7aR,12bS)-6-(2-(benzyloxy)propan-2-yl)-3-(cyclopropylmethyl)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: Reflux

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

3.1: tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere

3.2: Cooling with ice

4.1: potassium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 5 - 20 °C

4.2: 120 h / 20 °C

With hydrogen; potassium hydride; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; dimethyl sulfoxide; mineral oil;

Reference yield:

: 2579-67-1
northebaine

: 1367596-81-3
(4R,4aS,6R,7R,7aR,12bS)-6-(2-(benzyloxy)propan-2-yl)-3-(cyclopropylmethyl)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 90 °C

2.1: Reflux

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

4.1: tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere

4.2: Cooling with ice

5.1: potassium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 5 - 20 °C

5.2: 120 h / 20 °C

With hydrogen; potassium hydride; sodium hydrogencarbonate; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 24997-66-8
ethyl 17-(cyclopropylmethyl)-4,5α-epoxy-3,6β-dimethoxy-6,14-endoethenomorphinan-7α-carboxylate

: 1367596-81-3
(4R,4aS,6R,7R,7aR,12bS)-6-(2-(benzyloxy)propan-2-yl)-3-(cyclopropylmethyl)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

2.1: tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere

2.2: Cooling with ice

3.1: potassium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 5 - 20 °C

3.2: 120 h / 20 °C

With hydrogen; potassium hydride; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; dimethyl sulfoxide; mineral oil;