(2R,4S,5R,6S,7R,8R,9R)-2,7-Bis-benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-4-hydroxymethyl-6,8-dimethyl-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-undecan-5-ol

Base Information

• Chemical Name: (2R,4S,5R,6S,7R,8R,9R)-2,7-Bis-benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-4-hydroxymethyl-6,8-dimethyl-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-undecan-5-ol
• CAS No.: 123219-47-6
• Molecular Formula: C₄₅H₇₄O₇Si
• Molecular Weight: 755.164

Synonyms:

Chemical Property of (2R,4S,5R,6S,7R,8R,9R)-2,7-Bis-benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-4-hydroxymethyl-6,8-dimethyl-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-undecan-5-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4S,5R,6S,7R,8R,9R)-2,7-Bis-benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-4-hydroxymethyl-6,8-dimethyl-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-undecan-5-ol

There total 3 articles about (2R,4S,5R,6S,7R,8R,9R)-2,7-Bis-benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-4-hydroxymethyl-6,8-dimethyl-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-undecan-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S,4S,5R,6R,7R)-5-Benzyloxy-2-{(R)-2-benzyloxy-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-propyl}-7-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4,6-dimethyl-nonanoic acid methoxymethyl ester (123219-46-5,123287-23-0) → (2R,4S,5R,6S,7R,8R,9R)-2,7-Bis-benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-4-hydroxymethyl-6,8-dimethyl-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-undecan-5-ol (123219-47-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 0.25h;

DOI:10.1007/BF00953721

Reference yield:

(2R,3S,4R,5R)-3-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-heptanal (123219-41-0) → (2R,4S,5R,6S,7R,8R,9R)-2,7-Bis-benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-4-hydroxymethyl-6,8-dimethyl-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-undecan-5-ol (123219-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 17.4 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C / 1) 30 min, 2) 15 min

2: LiAlH₄ / diethyl ether / 0.25 h / 20 °C

With lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;

DOI:10.1007/BF00953721

Reference yield:

(R)-4-Benzyloxy-4-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-pentanoic acid methoxymethyl ester (123219-53-4) → (2R,4S,5R,6S,7R,8R,9R)-2,7-Bis-benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-4-hydroxymethyl-6,8-dimethyl-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-undecan-5-ol (123219-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 17.4 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C / 1) 30 min, 2) 15 min

2: LiAlH₄ / diethyl ether / 0.25 h / 20 °C

With lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;

DOI:10.1007/BF00953721

upstream raw materials:

(2R,3S,4S,5R,6R,7R)-5-Benzyloxy-2-{(R)-2-benzyloxy-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-propyl}-7-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4,6-dimethyl-nonanoic acid methoxymethyl ester

(2R,3S,4R,5R)-3-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-heptanal

(R)-4-Benzyloxy-4-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-pentanoic acid methoxymethyl ester

Downstream raw materials:

Methanesulfonic acid (2S,3R,4S,5R,6R,7R)-5-benzyloxy-2-{(R)-2-benzyloxy-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-propyl}-7-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4,6-dimethyl-nonyl ester

(2R,4R,5R,6S,7R,8R,9R)-2,7-Bis-benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-4,6,8-trimethyl-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-undecan-5-ol

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