Technology Process of (2R,5S)-1-methoxy-2,5-diphenylpyrrolidine
There total 4 articles about (2R,5S)-1-methoxy-2,5-diphenylpyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium cyanoborohydride; scandium tris(trifluoromethanesulfonate);
at 20 ℃;
for 2h;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1002/chem.201302735
- Guidance literature:
-
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 2.5 h / 20 °C / 750.08 Torr
2: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
3: sodium cyanoborohydride; scandium tris(trifluoromethanesulfonate) / 2 h / 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; scandium tris(trifluoromethanesulfonate);
In
tetrahydrofuran; ethanol;
DOI:10.1002/chem.201302735
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Hoveyda-Grubbs catalyst second generation / toluene / 2.5 h / 60 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / ethanol / 2.5 h / 20 °C / 750.08 Torr
3: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
4: sodium cyanoborohydride; scandium tris(trifluoromethanesulfonate) / 2 h / 20 °C / Inert atmosphere
With
Hoveyda-Grubbs catalyst second generation; palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; scandium tris(trifluoromethanesulfonate);
In
tetrahydrofuran; ethanol; toluene;
DOI:10.1002/chem.201302735
