Technology Process of BO-1965
There total 6 articles about BO-1965 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/jm301788a
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: water; methanol / 5 h / 20 °C
2.1: triethylamine / tetrahydrofuran / 9 h / Reflux
3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.25 h / 0 - 5 °C
3.2: 9 h / 0 - 20 °C
3.3: pH 6
4.1: acetic anhydride / 60 - 75 °C
5.1: lithium aluminium tetrahydride / diethyl ether; dichloromethane / 0.5 h / -5 - 0 °C
6.1: triethylamine / 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; acetic anhydride; sodium hydride; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; mineral oil;
1.1: |Pictet-Spengler Synthesis;
DOI:10.1021/jm301788a
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / tetrahydrofuran / 9 h / Reflux
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.25 h / 0 - 5 °C
2.2: 9 h / 0 - 20 °C
2.3: pH 6
3.1: acetic anhydride / 60 - 75 °C
4.1: lithium aluminium tetrahydride / diethyl ether; dichloromethane / 0.5 h / -5 - 0 °C
5.1: triethylamine / 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; acetic anhydride; sodium hydride; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; mineral oil;
DOI:10.1021/jm301788a
