trans-(7'R,11'R)-Phyllochinon

Base Information

• Chemical Name: trans-(7'R,11'R)-Phyllochinon
• CAS No.: 132487-94-6
• Molecular Formula: C₃₁H₄₆O₂
• Molecular Weight: 450.705
• Mol file: 132487-94-6.mol

Synonyms:

Chemical Property of trans-(7'R,11'R)-Phyllochinon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-(7'R,11'R)-Phyllochinon

There total 31 articles about trans-(7'R,11'R)-Phyllochinon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

trans-1,4-Dihydro-vitamin K1(20) (16869-68-4) → vitamin K1 (84-80-0,16033-41-3,27696-10-2,79082-95-4,79082-96-5,79082-97-6,79083-00-4,81818-54-4,105017-37-6,132487-93-5,132487-94-6,132487-95-7)

Guidance literature:

With dihydrogen peroxide; (Bu₃SnO)2CrO₂ on charcoal; In ethanol; at 40 ℃; for 1.5h;

DOI:10.1246/cl.1986.2075

Reference yield: 56.0%

→ vitamin K1 (84-80-0,16033-41-3,27696-10-2,79082-95-4,79082-96-5,79082-97-6,79083-00-4,81818-54-4,105017-37-6,132487-93-5,132487-94-6,132487-95-7)

Guidance literature:

With magnesium sulfate; silver(l) oxide; In diethyl ether;

Reference yield:

2-Bromo-3-Methyl-1,1,4,4-tetramethoxy-1,4-dihydronaphthalene (64648-85-7) + (7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl bromide (943232-38-0) → menadione (58-27-5,34524-96-4) + vitamin K1 (84-80-0,16033-41-3,27696-10-2,79082-95-4,79082-96-5,79082-97-6,79083-00-4,81818-54-4,105017-37-6,132487-93-5,132487-94-6,132487-95-7)

Guidance literature:

With hydrogenchloride; n-butyllithium; copper (I) iodide; dimethylsulfide; water; Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1021/jo01291a002

upstream raw materials:

menadione

C₁₃H₂₆Sn

2-Bromo-3-Methyl-1,1,4,4-tetramethoxy-1,4-dihydronaphthalene

(7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl bromide

Downstream raw materials:

vitamin K₁ chromenol

2-(3-hydroperoxy-3,7,11,15-tetramethyl-hexadec-1-en-t-yl)-3-methyl-[1,4]naphthoquinone

vitamin K₁ epoxide

6,10,14-Trimethyl-2-pentadecanon