C₂₁H₂₂ClFN₄O₃

Base Information

• Chemical Name: C₂₁H₂₂ClFN₄O₃
• CAS No.: 1456070-17-9
• Molecular Formula: C₂₁H₂₂ClFN₄O₃
• Molecular Weight: 432.882
• Mol file: 1456070-17-9.mol

Synonyms:

Chemical Property of C₂₁H₂₂ClFN₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₂ClFN₄O₃

There total 10 articles about C₂₁H₂₂ClFN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isovanillin (621-59-0) → C21H22ClFN4O3 (1456070-17-9)

Guidance literature:

Multi-step reaction with 10 steps

1: potassium carbonate / 60 °C

2: potassium permanganate / acetone / Reflux

3: thionyl chloride / Reflux

4: acetic anhydride; acetic acid; nitric acid / 0 - 5 °C

5: acetic acid; iron / methanol

6: ethanol / Reflux

7: trichlorophosphate; triethylamine / toluene / Reflux

8: isopropyl alcohol / Reflux

9: potassium iodide; acetone / Reflux

10: potassium carbonate

With potassium permanganate; thionyl chloride; nitric acid; acetic anhydride; iron; potassium carbonate; acetic acid; triethylamine; acetone; potassium iodide; trichlorophosphate; In methanol; ethanol; isopropyl alcohol; acetone; toluene;

DOI:10.1016/j.bmcl.2013.07.049

Reference yield:

3-(3-chloropropoxy)-4-methoxybenzaldehyde (929683-54-5) → C21H22ClFN4O3 (1456070-17-9)

Guidance literature:

Multi-step reaction with 9 steps

1: potassium permanganate / acetone / Reflux

2: thionyl chloride / Reflux

3: acetic anhydride; acetic acid; nitric acid / 0 - 5 °C

4: acetic acid; iron / methanol

5: ethanol / Reflux

6: trichlorophosphate; triethylamine / toluene / Reflux

7: isopropyl alcohol / Reflux

8: potassium iodide; acetone / Reflux

9: potassium carbonate

With potassium permanganate; thionyl chloride; nitric acid; acetic anhydride; iron; potassium carbonate; acetic acid; triethylamine; acetone; potassium iodide; trichlorophosphate; In methanol; ethanol; isopropyl alcohol; acetone; toluene;

DOI:10.1016/j.bmcl.2013.07.049

Reference yield:

3-(3-chloropropoxy)-4-methoxybenzoic acid → C21H22ClFN4O3 (1456070-17-9)

Guidance literature:

Multi-step reaction with 8 steps

1: thionyl chloride / Reflux

2: acetic anhydride; acetic acid; nitric acid / 0 - 5 °C

3: acetic acid; iron / methanol

4: ethanol / Reflux

5: trichlorophosphate; triethylamine / toluene / Reflux

6: isopropyl alcohol / Reflux

7: potassium iodide; acetone / Reflux

8: potassium carbonate

With thionyl chloride; nitric acid; acetic anhydride; iron; potassium carbonate; acetic acid; triethylamine; acetone; potassium iodide; trichlorophosphate; In methanol; ethanol; isopropyl alcohol; toluene;

DOI:10.1016/j.bmcl.2013.07.049

upstream raw materials:

isovanillin

3-(3-chloropropoxy)-4-methoxybenzaldehyde

methyl 3-(3-chloropropoxy)-4-methoxybenzoate

methyl 5-(3-chloropropoxy)-4-methoxy-2-nitrobenzoate

Refernces