(S)-N-(2,4-difluorobenzyl)-2'-ethyl-9'-hydroxy-1',8'-dioxo-1',2,2',4,4',5,6,8'-octahydrospiro[pyran-3,3'-pyrido[1,2-a]pyrazine]-7'-carboxamide

Base Information

Chemical Name:(S)-N-(2,4-difluorobenzyl)-2'-ethyl-9'-hydroxy-1',8'-dioxo-1',2,2',4,4',5,6,8'-octahydrospiro[pyran-3,3'-pyrido[1,2-a]pyrazine]-7'-carboxamide
CAS No.:1799952-48-9
Molecular Formula:C₂₂H₂₃F₂N₃O₅
Molecular Weight:447.439
Hs Code.:
Mol file:1799952-48-9.mol

Synonyms:

Suppliers and Price of (S)-N-(2,4-difluorobenzyl)-2'-ethyl-9'-hydroxy-1',8'-dioxo-1',2,2',4,4',5,6,8'-octahydrospiro[pyran-3,3'-pyrido[1,2-a]pyrazine]-7'-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (S)-N-(2,4-difluorobenzyl)-2'-ethyl-9'-hydroxy-1',8'-dioxo-1',2,2',4,4',5,6,8'-octahydrospiro[pyran-3,3'-pyrido[1,2-a]pyrazine]-7'-carboxamide

Chemical Property:

Boiling Point:686.9±55.0 °C(Predicted)
PKA:4.50±1.00(Predicted)
Density:1.46±0.1 g/cm3(Predicted)

Purity/Quality:: ≥98.0%, ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (S)-N-(2,4-difluorobenzyl)-2'-ethyl-9'-hydroxy-1',8'-dioxo-1',2,2',4,4',5,6,8'-octahydrospiro[pyran-3,3'-pyrido[1,2-a]pyrazine]-7'-carboxamide

There total 8 articles about (S)-N-(2,4-difluorobenzyl)-2'-ethyl-9'-hydroxy-1',8'-dioxo-1',2,2',4,4',5,6,8'-octahydrospiro[pyran-3,3'-pyrido[1,2-a]pyrazine]-7'-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₉F₂N₃O₅

: 1799952-48-9
C₂₂H₂₃F₂N₃O₅

Guidance literature:: With lithium chloride; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

: C₂₁H₂₃BrN₂O₄

: 1799952-48-9
C₂₂H₂₃F₂N₃O₅

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine / methanol; dimethyl sulfoxide / 3 h / 80 °C / 760.05 Torr

2: lithium chloride / N,N-dimethyl-formamide / 2 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; lithium chloride; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: C₈H₁₄N₂O

: 1799952-48-9
C₂₂H₂₃F₂N₃O₅

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 18 °C

2.1: triethylamine / dichloromethane / 16 h / 18 °C

3.1: chloro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.67 h / 15 °C

3.2: 16 h / 15 °C

4.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 16 °C

4.2: 16 h / 80 °C

5.1: N-Bromosuccinimide / dichloromethane / 1 h / 18 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine / methanol; dimethyl sulfoxide / 3 h / 80 °C / 760.05 Torr

7.1: lithium chloride / N,N-dimethyl-formamide / 2 h / 100 °C

With N-Bromosuccinimide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;