3,4,5,7-tetrahydro-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione

Base Information

• Chemical Name: 3,4,5,7-tetrahydro-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione
• CAS No.: 130475-30-8
• Molecular Formula: C₂₂H₂₄N₄O₃S
• Molecular Weight: 424.524
• Mol file: 130475-30-8.mol

Synonyms:

Chemical Property of 3,4,5,7-tetrahydro-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4,5,7-tetrahydro-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione

There total 7 articles about 3,4,5,7-tetrahydro-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3,4,5,7,8,9-hexahydro-9-hydroxy-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione (130475-27-3) → 3,4,5,7-tetrahydro-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione (130475-30-8)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; for 16h; Heating;

Reference yield:

methyl 3-amino-4-thiophenecarboxylate hydrochloride (39978-14-8) → 3,4,5,7-tetrahydro-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione (130475-30-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 84 percent / aq. NaOH / CH₂Cl₂ / 2 h / Ambient temperature

2: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

3: 75 percent / aq. C₆H₅CH₂N(CH₃)3OH / CHCl₃; methanol / 2 h / Heating

4: 28 percent / 50percent aq. NaOH / methanol / 2 h / Heating

5: 61 percent / P₂O₅, CH₃SO₃H (1:10 / 2 h / Ambient temperature

6: 58 percent / NaBH₄ / ethanol / 72 h / Ambient temperature

7: 50 percent / CH₃SO₂Cl, NEt₃ / CH₂Cl₂ / 16 h / Heating

With sodium hydroxide; sodium tetrahydroborate; methanesulfonic acid; trimethylaluminum; phosphorus pentoxide; N-benzyl-trimethylammonium hydroxide; methanesulfonyl chloride; triethylamine; In methanol; ethanol; dichloromethane; chloroform; toluene;

Reference yield:

ethyl (4-methoxycarbonyl)thiophene-3-carbamate (118252-16-7) → 3,4,5,7-tetrahydro-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione (130475-30-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

2: 75 percent / aq. C₆H₅CH₂N(CH₃)3OH / CHCl₃; methanol / 2 h / Heating

3: 28 percent / 50percent aq. NaOH / methanol / 2 h / Heating

4: 61 percent / P₂O₅, CH₃SO₃H (1:10 / 2 h / Ambient temperature

5: 58 percent / NaBH₄ / ethanol / 72 h / Ambient temperature

6: 50 percent / CH₃SO₂Cl, NEt₃ / CH₂Cl₂ / 16 h / Heating

With sodium hydroxide; sodium tetrahydroborate; methanesulfonic acid; trimethylaluminum; phosphorus pentoxide; N-benzyl-trimethylammonium hydroxide; methanesulfonyl chloride; triethylamine; In methanol; ethanol; dichloromethane; chloroform; toluene;

upstream raw materials:

3,4,5,7,8,9-hexahydro-9-hydroxy-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione

methyl 3-amino-4-thiophenecarboxylate hydrochloride

ethyl (4-methoxycarbonyl)thiophene-3-carbamate

3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione