Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester

Base Information

• Chemical Name: Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester
• CAS No.: 85562-02-3
• Molecular Formula: C₅₁H₅₆N₅O₁₃PS
• Molecular Weight: 1010.07

Synonyms:

Chemical Property of Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester

There total 6 articles about Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(bis-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester (85562-01-2) → Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester (85562-02-3)

Guidance literature:

With hypophosphorous acid; triethylamine; In pyridine; at 40 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)87448-2

Reference yield:

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine (68892-41-1) → Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester (85562-02-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 94 percent / pyridine / 2 h / Ambient temperature

2: 81 percent / DDS / pyridine / 2 h / Ambient temperature

3: pyridine / coevaporation

4: 91 percent / 3 h / Ambient temperature

5: phosphinic acid-Et₃N / pyridine / 0.5 h / 40 °C

With hypophosphorous acid; triethylamine; dapsone; In pyridine;

DOI:10.1016/S0040-4020(01)87448-2

Reference yield:

cyclohexylammonium S,S-diphenyl phosphorodithioate (67941-87-1) → Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester (85562-02-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 81 percent / DDS / pyridine / 2 h / Ambient temperature

2: pyridine / coevaporation

3: 91 percent / 3 h / Ambient temperature

4: phosphinic acid-Et₃N / pyridine / 0.5 h / 40 °C

With hypophosphorous acid; triethylamine; dapsone; In pyridine;

DOI:10.1016/S0040-4020(01)87448-2

upstream raw materials:

Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(bis-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester

cyclohexylammonium S,S-diphenyl phosphorodithioate

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

S,S-diphenyl N²-isobutyryl-5'-O-dimethoxytritylguanosine 3'-phosphorodithioate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 85562-02-3 Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send