Technology Process of C27H30BF3N4O4
There total 7 articles about C27H30BF3N4O4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / tetrahydrofuran / 10 h / Inert atmosphere; Reflux
2.1: trifluoroacetic acid / 1,2-dichloro-ethane / 4 h / Inert atmosphere; Reflux
2.2: 2 h / 20 °C / Inert atmosphere
3.1: triethylamine / dichloromethane / 8 h / 20 °C / Inert atmosphere
4.1: tetrakis(triphenylphosphine) palladium(0) / ethanol / 8 h / Inert atmosphere; Reflux
5.1: sodium hypochlorite / aq. phosphate buffer; N,N-dimethyl-formamide / 0.5 h / pH 7.4
With
sodium hypochlorite; tetrakis(triphenylphosphine) palladium(0); potassium carbonate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; aq. phosphate buffer; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/ol501496n
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid / 1,2-dichloro-ethane / 4 h / Inert atmosphere; Reflux
1.2: 2 h / 20 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 8 h / 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / ethanol / 8 h / Inert atmosphere; Reflux
4.1: sodium hypochlorite / aq. phosphate buffer; N,N-dimethyl-formamide / 0.5 h / pH 7.4
With
sodium hypochlorite; tetrakis(triphenylphosphine) palladium(0); triethylamine; trifluoroacetic acid;
In
aq. phosphate buffer; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/ol501496n
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 8 h / 20 °C / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0) / ethanol / 8 h / Inert atmosphere; Reflux
3: sodium hypochlorite / aq. phosphate buffer; N,N-dimethyl-formamide / 0.5 h / pH 7.4
With
sodium hypochlorite; tetrakis(triphenylphosphine) palladium(0); triethylamine;
In
aq. phosphate buffer; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol501496n