(4R)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate

Base Information

• Chemical Name: (4R)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate
• CAS No.: 1616389-35-5
• Molecular Formula: C₄₀H₄₉N₄O₇P
• Molecular Weight: 728.825
• Mol file: 1616389-35-5.mol

Synonyms:

Chemical Property of (4R)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate

There total 3 articles about (4R)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C31H32N2O6 (1651865-12-1) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → (4R)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate (1616389-35-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1039/c4ob00149d

Reference yield:

1,5,6,7-tetrahydro-cyclopentapyrimidine-2,4-dione (5466-00-2) → (4R)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate (1616389-35-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 80 °C

1.2: 80 °C / Inert atmosphere

2.1: dmap; pyridine / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 20 °C / Inert atmosphere

With pyridine; dmap; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c4ob00149d

Reference yield:

2-ethoxycarbonyl-1-cyclopentanone (611-10-9) → (4R)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate (1616389-35-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / ethanol / 3 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 80 °C

2.2: 80 °C / Inert atmosphere

3.1: dmap; pyridine / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; dmap; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c4ob00149d

upstream raw materials:

C₃₁H₃₂N₂O₆

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

1,5,6,7-tetrahydro-cyclopentapyrimidine-2,4-dione

2-ethoxycarbonyl-1-cyclopentanone