(S)-N-{(S)-[(S)-4-({Amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-1-(benzyloxycarbonylmethyl-methyl-carbamoyl)-butylcarbamoyl]-phenyl-methyl}-3-tert-butoxycarbonylamino-succinamic acid cyclohexyl ester

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Chemical Name:(S)-N-{(S)-[(S)-4-({Amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-1-(benzyloxycarbonylmethyl-methyl-carbamoyl)-butylcarbamoyl]-phenyl-methyl}-3-tert-butoxycarbonylamino-succinamic acid cyclohexyl ester
CAS No.:146878-13-9
Molecular Formula:C₄₆H₆₁N₇O₁₁S
Molecular Weight:920.097
Hs Code.:

(S)-N-{(S)-[(S)-4-({Amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-1-(benzyloxycarbonylmethyl-methyl-carbamoyl)-butylcarbamoyl]-phenyl-methyl}-3-tert-butoxycarbonylamino-succinamic acid cyclohexyl ester

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Chemical Property of (S)-N-{(S)-[(S)-4-({Amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-1-(benzyloxycarbonylmethyl-methyl-carbamoyl)-butylcarbamoyl]-phenyl-methyl}-3-tert-butoxycarbonylamino-succinamic acid cyclohexyl ester

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Technology Process of (S)-N-{(S)-[(S)-4-({Amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-1-(benzyloxycarbonylmethyl-methyl-carbamoyl)-butylcarbamoyl]-phenyl-methyl}-3-tert-butoxycarbonylamino-succinamic acid cyclohexyl ester

There total 1 articles about (S)-N-{(S)-[(S)-4-({Amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-1-(benzyloxycarbonylmethyl-methyl-carbamoyl)-butylcarbamoyl]-phenyl-methyl}-3-tert-butoxycarbonylamino-succinamic acid cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73821-95-1
Boc-Asp(O-cyclohexyl)-OH

: {[(S)-2-((S)-2-Amino-2-phenyl-acetylamino)-5-({amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-pentanoyl]-methyl-amino}-acetic acid benzyl ester; compound with trifluoro-acetic acid

: 146878-13-9
(S)-N-{(S)-[(S)-4-({Amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-1-(benzyloxycarbonylmethyl-methyl-carbamoyl)-butylcarbamoyl]-phenyl-methyl}-3-tert-butoxycarbonylamino-succinamic acid cyclohexyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at -0.1 ℃; for 24h; Yield given;
DOI:10.1039/p19960000939

Reference yield:

: 146878-13-9
(S)-N-{(S)-[(S)-4-({Amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-1-(benzyloxycarbonylmethyl-methyl-carbamoyl)-butylcarbamoyl]-phenyl-methyl}-3-tert-butoxycarbonylamino-succinamic acid cyclohexyl ester

: 146878-15-1
(S)-N-{(S)-[(S)-4-({Amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-1-(carboxymethyl-methyl-carbamoyl)-butylcarbamoyl]-phenyl-methyl}-3-tert-butoxycarbonylamino-succinamic acid cyclohexyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 3h; Yield given;
DOI:10.1039/p19960000939

Reference yield:

: 146878-13-9
(S)-N-{(S)-[(S)-4-({Amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-1-(benzyloxycarbonylmethyl-methyl-carbamoyl)-butylcarbamoyl]-phenyl-methyl}-3-tert-butoxycarbonylamino-succinamic acid cyclohexyl ester

: (S)-3-Amino-N-{(S)-[(S)-4-({amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-1-(carboxymethyl-methyl-carbamoyl)-butylcarbamoyl]-phenyl-methyl}-succinamic acid cyclohexyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / methanol / 3 h

2: 93 percent / HCl / dioxane / 2 h

With hydrogenchloride; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol;
DOI:10.1039/p19960000939