{(2R,3R,4R,5S,6S)-4,5-Bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-tetrahydro-pyran-2-yl}-acetonitrile

Base Information

Chemical Name:{(2R,3R,4R,5S,6S)-4,5-Bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-tetrahydro-pyran-2-yl}-acetonitrile
CAS No.:250660-86-7
Molecular Formula:C₄₆H₆₁NO₅Si₂
Molecular Weight:764.165
Hs Code.:

{(2R,3R,4R,5S,6S)-4,5-Bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-tetrahydro-pyran-2-yl}-acetonitrile

Synonyms:

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Chemical Property of {(2R,3R,4R,5S,6S)-4,5-Bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-tetrahydro-pyran-2-yl}-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
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Useful:

Technology Process of {(2R,3R,4R,5S,6S)-4,5-Bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-tetrahydro-pyran-2-yl}-acetonitrile

There total 7 articles about {(2R,3R,4R,5S,6S)-4,5-Bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-tetrahydro-pyran-2-yl}-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: {(2R,3R,4S,5S,6S)-4,5-Bis-benzyloxy-6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3-hydroxy-tetrahydro-pyran-2-yl}-acetonitrile

: 250660-86-7
{(2R,3R,4R,5S,6S)-4,5-Bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-tetrahydro-pyran-2-yl}-acetonitrile

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1055/s-1999-3646

Reference yield:

: 173613-44-0
(2S,3R,4R,5S,6R)-2-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol

: 250660-86-7
{(2R,3R,4R,5S,6S)-4,5-Bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-tetrahydro-pyran-2-yl}-acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: PPTs / CH₂Cl₂ / 20 °C

2: NaH / tetrahydrofuran; dimethylformamide / 0 - 20 °C

3: DIBAL / CH₂Cl₂ / -20 °C

4: pyridine; DMAP / CH₂Cl₂ / 20 °C

5: 18-crown-6 / dimethylformamide / 80 °C

6: DDQ; H₂O / CH₂Cl₂ / 20 °C

7: 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

With pyridine; 2,6-dimethylpyridine; dmap; 18-crown-6 ether; water; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Etherification / 3: Reduction / 4: Tosylation / 5: Substitution / 6: Hydrolysis / 7: Etherification;
DOI:10.1055/s-1999-3646

Reference yield:

: (4aR,6S,7R,8R,8aS)-6-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

: 250660-86-7
{(2R,3R,4R,5S,6S)-4,5-Bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-tetrahydro-pyran-2-yl}-acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: NaH / tetrahydrofuran; dimethylformamide / 0 - 20 °C

2: DIBAL / CH₂Cl₂ / -20 °C

3: pyridine; DMAP / CH₂Cl₂ / 20 °C

4: 18-crown-6 / dimethylformamide / 80 °C

5: DDQ; H₂O / CH₂Cl₂ / 20 °C

6: 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

With pyridine; 2,6-dimethylpyridine; dmap; 18-crown-6 ether; water; sodium hydride; diisobutylaluminium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Etherification / 2: Reduction / 3: Tosylation / 4: Substitution / 5: Hydrolysis / 6: Etherification;
DOI:10.1055/s-1999-3646