<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>acetic acid tert-butyl ester

Base Information

Chemical Name:<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>acetic acid tert-butyl ester
CAS No.:147961-14-6
Molecular Formula:C₃₈H₃₉ClN₂O₄S
Molecular Weight:655.258
Hs Code.:

<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>acetic acid tert-butyl ester

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Chemical Property of <2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>acetic acid tert-butyl ester

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Technology Process of <2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>acetic acid tert-butyl ester

There total 4 articles about <2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 155143-17-2
ethyl <1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>acetate

: 147961-14-6
<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 19 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

2: Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

3: 1.) NaH, 2.) n-Bu₄NI / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, 18 h

With lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00034a013

Reference yield:

: [5-Allyloxy-3-tert-butylsulfanyl-1-(4-chloro-benzyl)-1H-indol-2-yl]-acetic acid ethyl ester

: 147961-14-6
<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) p-TSA / 1.) 1,2-dichlorobenzene, 200 deg C, 7 h, 2.) 1,2-dichlorobenzene, 150 deg C, 30 min

2: 19 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3: Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

4: 1.) NaH, 2.) n-Bu₄NI / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, 18 h

With lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00034a013

Reference yield:

: 1-(4-chlorobenzyl)-1-(4-allyloxy phenyl)hydrazine hydrochloride

: 147961-14-6
<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: AcONa, AcOH / toluene / 1.5 h / 70 °C

2: 2.) p-TSA / 1.) 1,2-dichlorobenzene, 200 deg C, 7 h, 2.) 1,2-dichlorobenzene, 150 deg C, 30 min

3: 19 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

4: Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

5: 1.) NaH, 2.) n-Bu₄NI / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, 18 h

With lithium aluminium tetrahydride; sodium acetate; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm00034a013