Acetic acid, [(5-chloro-3,4-dihydro-4-oxo-3-phenyl-7-quinazolinyl)oxy]-

Base Information

Chemical Name:Acetic acid, [(5-chloro-3,4-dihydro-4-oxo-3-phenyl-7-quinazolinyl)oxy]-
CAS No.:137986-08-4
Molecular Formula:C₁₆H₁₁ClN₂O₄
Molecular Weight:330.727
Hs Code.:
Mol file:137986-08-4.mol

Synonyms:

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Chemical Property of Acetic acid, [(5-chloro-3,4-dihydro-4-oxo-3-phenyl-7-quinazolinyl)oxy]-

Chemical Property:

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Technology Process of Acetic acid, [(5-chloro-3,4-dihydro-4-oxo-3-phenyl-7-quinazolinyl)oxy]-

There total 9 articles about Acetic acid, [(5-chloro-3,4-dihydro-4-oxo-3-phenyl-7-quinazolinyl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (5-Chloro-4-oxo-3-phenyl-3,4-dihydro-quinazolin-7-yloxy)-acetic acid ethyl ester

: 137986-08-4
((5-chloro-3,4-dihydro-4-oxo-3-phenyl-3H-quinazolin-7-yl)oxy)acetic acid

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide; for 1h; Yield given; Heating;
DOI:10.1248/cpb.39.2400

Reference yield:

: 29105-95-1
2-chloro-4-methoxy-6-nitroaniline

: 137986-08-4
((5-chloro-3,4-dihydro-4-oxo-3-phenyl-3H-quinazolin-7-yl)oxy)acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 1) NaNO₂, conc. H₂SO₄, 2) Na₂CO₃ / 1) acetic acid, room temperature, 2) H₂O, room temperature, 3 h

2: 78 percent / conc. H₂SO₄, NaNO₂ / acetic acid; H₂O / a) 140 deg C, b) 100 deg C, 30 min

3: SOCl₂ / 1 h / Heating

4: benzene / 2 h / Ambient temperature

5: 84 percent / SnCl₂*2H₂O, conc. aq. HCl / ethanol / 3 h / Ambient temperature

6: 57 percent / 2 h / Heating

7: 61 percent / AlCl₃ / benzene / 2 h / Heating

8: K₂CO₃ / dimethylformamide / 2 h / 60 °C

9: 10percent aq. NaOH / dimethylformamide / 1 h / Heating

With hydrogenchloride; sodium hydroxide; aluminium trichloride; thionyl chloride; sulfuric acid; sodium carbonate; potassium carbonate; tin(ll) chloride; sodium nitrite; In ethanol; water; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.39.2400

Reference yield:

: 137986-04-0
2-chloro-4-methoxy-6-nitrobenzoic acid

: 137986-08-4
((5-chloro-3,4-dihydro-4-oxo-3-phenyl-3H-quinazolin-7-yl)oxy)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / 1 h / Heating

2: benzene / 2 h / Ambient temperature

3: 84 percent / SnCl₂*2H₂O, conc. aq. HCl / ethanol / 3 h / Ambient temperature

4: 57 percent / 2 h / Heating

5: 61 percent / AlCl₃ / benzene / 2 h / Heating

6: K₂CO₃ / dimethylformamide / 2 h / 60 °C

7: 10percent aq. NaOH / dimethylformamide / 1 h / Heating

With hydrogenchloride; sodium hydroxide; aluminium trichloride; thionyl chloride; potassium carbonate; tin(ll) chloride; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.39.2400