3,5-di-iodo-3'<(2-oxo-2,3-dihydrothiazol-5-yl)methyl>-L-thyronine

Base Information

Chemical Name:3,5-di-iodo-3'<(2-oxo-2,3-dihydrothiazol-5-yl)methyl>-L-thyronine
CAS No.:120130-01-0
Molecular Formula:C₁₉H₁₆I₂N₂O₅S
Molecular Weight:638.221
Hs Code.:

Synonyms:

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Chemical Property of 3,5-di-iodo-3'<(2-oxo-2,3-dihydrothiazol-5-yl)methyl>-L-thyronine

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Technology Process of 3,5-di-iodo-3'<(2-oxo-2,3-dihydrothiazol-5-yl)methyl>-L-thyronine

There total 8 articles about 3,5-di-iodo-3'<(2-oxo-2,3-dihydrothiazol-5-yl)methyl>-L-thyronine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52329-06-3
5-(benzyloxy)-2-methoxybenzaldehyde

: 120130-01-0
3,5-di-iodo-3'<(2-oxo-2,3-dihydrothiazol-5-yl)methyl>-L-thyronine

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent / sodium borohydride / methanol

2: 81 percent / phosphorus tribromide / CH₂Cl₂ / -5 °C

3: 74 percent / butyl-lithium / hexane; tetrahydrofuran / -78 - -70 °C

4: 72 percent / 10 M hydrochloric acid / methanol; H₂O / Heating

5: 60 percent / 1M boron trichloride / CH₂Cl₂ / -78 deg C, -20 deg C, 1 h

6: 41 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating

7: H₂ / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr

8: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h

9: 1.) boron tribromide, 2.) 2M-NaOH / 1.) methylene dichloride, 0 deg C, RT, 1.5 h, 2.) 100 deg C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; sulfuric acid; hydrogen; iodine; boron trichloride; boron tribromide; phosphorus tribromide; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; water; acetic acid;
DOI:10.1039/P19880003085

Reference yield:

: 105170-17-0
5-benzyloxy-2-methoxy-benzyl bromide

: 120130-01-0
3,5-di-iodo-3'<(2-oxo-2,3-dihydrothiazol-5-yl)methyl>-L-thyronine

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / butyl-lithium / hexane; tetrahydrofuran / -78 - -70 °C

2: 72 percent / 10 M hydrochloric acid / methanol; H₂O / Heating

3: 60 percent / 1M boron trichloride / CH₂Cl₂ / -78 deg C, -20 deg C, 1 h

4: 41 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating

5: H₂ / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr

6: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h

7: 1.) boron tribromide, 2.) 2M-NaOH / 1.) methylene dichloride, 0 deg C, RT, 1.5 h, 2.) 100 deg C

With hydrogenchloride; sodium hydroxide; n-butyllithium; sulfuric acid; hydrogen; iodine; boron trichloride; boron tribromide; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; water; acetic acid;
DOI:10.1039/P19880003085

Reference yield:

: 120147-87-7
5-<(5-hydroxy-2-methoxyphenyl)methyl>thiazol-2-(3H)-one

: 120130-01-0
3,5-di-iodo-3'<(2-oxo-2,3-dihydrothiazol-5-yl)methyl>-L-thyronine

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating

2: H₂ / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr

3: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h

4: 1.) boron tribromide, 2.) 2M-NaOH / 1.) methylene dichloride, 0 deg C, RT, 1.5 h, 2.) 100 deg C

With sodium hydroxide; sulfuric acid; hydrogen; iodine; boron tribromide; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite; palladium on activated charcoal; In pyridine; acetic acid;
DOI:10.1039/P19880003085