5-[4-tert-Butoxycarbonyl-6-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-1-isopropenyl-hexyl]-2-phenylsulfanylmethyl-furan-3-carboxylic acid methyl ester

Base Information

Chemical Name:5-[4-tert-Butoxycarbonyl-6-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-1-isopropenyl-hexyl]-2-phenylsulfanylmethyl-furan-3-carboxylic acid methyl ester
CAS No.:139897-41-9
Molecular Formula:C₄₃H₅₄O₇SSi
Molecular Weight:743.049
Hs Code.:

5-[4-tert-Butoxycarbonyl-6-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-1-isopropenyl-hexyl]-2-phenylsulfanylmethyl-furan-3-carboxylic acid methyl ester

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Chemical Property of 5-[4-tert-Butoxycarbonyl-6-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-1-isopropenyl-hexyl]-2-phenylsulfanylmethyl-furan-3-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 5-[4-tert-Butoxycarbonyl-6-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-1-isopropenyl-hexyl]-2-phenylsulfanylmethyl-furan-3-carboxylic acid methyl ester

There total 7 articles about 5-[4-tert-Butoxycarbonyl-6-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-1-isopropenyl-hexyl]-2-phenylsulfanylmethyl-furan-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 126822-60-4
4-(tert-Butyl-diphenyl-silanyloxy)-2-(2-oxo-ethyl)-butyric acid tert-butyl ester

: 126822-59-1,126822-68-2
methyl 2-<(phenylthio)methyl>-5-<3-(tri-n-butylstannyl)-2-methyl-1-propenyl>-3-furoate

: 139897-41-9,139974-72-4,139974-73-5,139974-74-6
5-[4-tert-Butoxycarbonyl-6-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-1-isopropenyl-hexyl]-2-phenylsulfanylmethyl-furan-3-carboxylic acid methyl ester

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 0.166667h;

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 139897-41-9,139974-72-4,139974-73-5,139974-74-6
5-[4-tert-Butoxycarbonyl-6-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-1-isopropenyl-hexyl]-2-phenylsulfanylmethyl-furan-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) lithium diisopropylamide, 2.) 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidone (DMPU) / 1.) THF, -78 deg C, 45 min, 2.) THF, a) -78 deg C, 30 min, b) RT, 18 h

2: 1.) lithium diisopropylamide / 1.) hexane, THF, -78 deg C, 45 min, 2.) hexane, THF, -78 deg C, 1 h

3: 1.) ozone, 2.) PPh₃ / 1.) CH₂Cl₂, -78 deg C, 10 min, 2.) CH₂Cl₂, RT, 5 h

4: 86 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.17 h / -78 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; boron trifluoride diethyl etherate; ozone; triphenylphosphine; lithium diisopropyl amide; In dichloromethane;

Reference yield:

: 126822-71-7
1-iodo-2-<(tert-butyldiphenylsilyl)oxy>ethane

: 139897-41-9,139974-72-4,139974-73-5,139974-74-6
5-[4-tert-Butoxycarbonyl-6-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-1-isopropenyl-hexyl]-2-phenylsulfanylmethyl-furan-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) lithium diisopropylamide, 2.) 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidone (DMPU) / 1.) THF, -78 deg C, 45 min, 2.) THF, a) -78 deg C, 30 min, b) RT, 18 h

2: 1.) lithium diisopropylamide / 1.) hexane, THF, -78 deg C, 45 min, 2.) hexane, THF, -78 deg C, 1 h

3: 1.) ozone, 2.) PPh₃ / 1.) CH₂Cl₂, -78 deg C, 10 min, 2.) CH₂Cl₂, RT, 5 h

4: 86 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.17 h / -78 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; boron trifluoride diethyl etherate; ozone; triphenylphosphine; lithium diisopropyl amide; In dichloromethane;