Technology Process of N5-(2-(4-([1,1’-biphenyl]-4-yl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]trizaine-5,7-diamine
There total 6 articles about N5-(2-(4-([1,1’-biphenyl]-4-yl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]trizaine-5,7-diamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
LUF5443;
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 - 20 ℃;
2-(4-(biphenyl-4-yl)piperazin-1-yl)ethanamine;
In
acetonitrile;
Reflux;
DOI:10.1002/cmdc.201300474
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 72 h / 20 °C
2.1: water; ethyl acetate / 3 h / 20 °C
3.1: dichloromethane; methanol / 5.5 h / 20 - 180 °C / Inert atmosphere; Reflux
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
4.2: Reflux
With
3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
methanol; dichloromethane; water; ethyl acetate;
DOI:10.1002/cmdc.201300474
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrazine hydrate / ethanol / 70 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
2.2: Reflux
With
hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid;
In
ethanol; dichloromethane;
DOI:10.1002/cmdc.201300474