C₃₅H₄₈N₂O₆Si

Base Information

• Chemical Name: C₃₅H₄₈N₂O₆Si
• CAS No.: 221526-61-0
• Molecular Formula: C₃₅H₄₈N₂O₆Si
• Molecular Weight: 620.861
• Mol file: 221526-61-0.mol

Synonyms:

Chemical Property of C₃₅H₄₈N₂O₆Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₅H₄₈N₂O₆Si

There total 16 articles about C₃₅H₄₈N₂O₆Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Benzenesulfonyl-3,4,5,6-tetrahydropyridin-2-one (7744-25-4) → C35H48N2O6Si (221526-61-0)

Guidance literature:

Multi-step reaction with 14 steps

1: 73 percent / LiN(TMS)2 / tetrahydrofuran / 11 h / -60 °C

2: LiN(TMS)2 / tetrahydrofuran / 2 h / -60 °C

3: n-Bu₃SnH, AIBN / benzene / 0.5 h / Heating

4: KN(TMS)2 / tetrahydrofuran / -30 °C

5: mCPBA / CH₂Cl₂

6: various solvent(s) / 20 h / 180 °C

7: PPTS / CH₂Cl₂

8: 21 percent / HCl / tetrahydrofuran / 2 h / Heating

9: HCl

10: imidazole / dimethylformamide / 2 h / Ambient temperature

11: p-TsOH / benzene / 2 h / Heating

12: 94 percent / sodium anthracenide / 1,2-dimethoxy-ethane / 2 h / -65 °C

13: sodium naphthalenide / 1,2-dimethoxy-ethane / 2 h / -65 °C

14: aq. NaOH / 12 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; sodium hydroxide; sodium anthracenide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; sodium naphthalenide; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; benzene;

DOI:10.1016/S0040-4039(98)80033-6

Reference yield:

1-benzenesulfonyl-3-[(4R)-3-benzenesulfonyl-2,2-dimethyloxazolidin-4-ylmethyl]-5,6-dihydro-1H-pyridin-2-one (221526-77-8) → C35H48N2O6Si (221526-61-0)

Guidance literature:

Multi-step reaction with 9 steps

1: various solvent(s) / 20 h / 180 °C

2: PPTS / CH₂Cl₂

3: 21 percent / HCl / tetrahydrofuran / 2 h / Heating

4: HCl

5: imidazole / dimethylformamide / 2 h / Ambient temperature

6: p-TsOH / benzene / 2 h / Heating

7: 94 percent / sodium anthracenide / 1,2-dimethoxy-ethane / 2 h / -65 °C

8: sodium naphthalenide / 1,2-dimethoxy-ethane / 2 h / -65 °C

9: aq. NaOH / 12 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; sodium hydroxide; sodium anthracenide; pyridinium p-toluenesulfonate; sodium naphthalenide; toluene-4-sulfonic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; benzene;

DOI:10.1016/S0040-4039(98)80033-6

Reference yield:

(RS)-1-benzenesulfonyl-3-[(4R)-3-benzenesulfonyl-2,2-dimethyloxazolidin-4-ylmethyl]-piperidin-2-one (221526-73-4) → C35H48N2O6Si (221526-61-0)

Guidance literature:

Multi-step reaction with 11 steps

1: KN(TMS)2 / tetrahydrofuran / -30 °C

2: mCPBA / CH₂Cl₂

3: various solvent(s) / 20 h / 180 °C

4: PPTS / CH₂Cl₂

5: 21 percent / HCl / tetrahydrofuran / 2 h / Heating

6: HCl

7: imidazole / dimethylformamide / 2 h / Ambient temperature

8: p-TsOH / benzene / 2 h / Heating

9: 94 percent / sodium anthracenide / 1,2-dimethoxy-ethane / 2 h / -65 °C

10: sodium naphthalenide / 1,2-dimethoxy-ethane / 2 h / -65 °C

11: aq. NaOH / 12 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; sodium hydroxide; sodium anthracenide; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; sodium naphthalenide; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; benzene;

DOI:10.1016/S0040-4039(98)80033-6

upstream raw materials:

di-tert-butyl dicarbonate

1-Benzenesulfonyl-3,4,5,6-tetrahydropyridin-2-one

tert-butylchlorodiphenylsilane

(RS)-1-benzenesulfonyl-3-[(4R)-3-benzenesulfonyl-2,2-dimethyloxazolidin-4-ylmethyl]-piperidin-2-one