(R)-2-isobutyl-4-oxo-(S)-5-phenylheptanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

Base Information

Chemical Name:(R)-2-isobutyl-4-oxo-(S)-5-phenylheptanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide
CAS No.:209664-23-3
Molecular Formula:C₂₃H₃₇NO₃
Molecular Weight:375.552
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-isobutyl-4-oxo-(S)-5-phenylheptanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

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Technology Process of (R)-2-isobutyl-4-oxo-(S)-5-phenylheptanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

There total 4 articles about (R)-2-isobutyl-4-oxo-(S)-5-phenylheptanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7533-40-6,14438-11-0
(S)-2-amino-4-methylpentan-1-ol

: 176969-23-6
2-isobutyl-4-oxo-(S)-5-phenylheptanoic acid

: 209664-23-3
(R)-2-isobutyl-4-oxo-(S)-5-phenylheptanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 - 23 ℃; Yield given;
DOI:10.1016/S0968-0896(98)00009-1

Reference yield:

: 4286-15-1
(S)-2-phenylbutyric acid

: 209664-23-3
(R)-2-isobutyl-4-oxo-(S)-5-phenylheptanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 1,1'-carbonyldiimidazole / 1.) THF, 0 deg C, 0.5 h; room temperature, overnight, 2.) THF, hexane, -78 deg C, 0.5 h

2: 1.) NaH / 1.) THF, room temperature, overnight, 2.) TFA, room temperature, 3.) benzene, reflux

3: LiOH*H₂O / methanol; H₂O / 70 - 75 °C

4: N-methylmorpholine, 1-HOBt, BOP / dimethylformamide / 0 - 23 °C

With 4-methyl-morpholine; lithium hydroxide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 1,1'-carbonyldiimidazole; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00009-1

Reference yield:

: 176969-21-4
(S)-3-Oxo-4-phenyl-hexanoic acid tert-butyl ester

: 209664-23-3
(R)-2-isobutyl-4-oxo-(S)-5-phenylheptanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, room temperature, overnight, 2.) TFA, room temperature, 3.) benzene, reflux

2: LiOH*H₂O / methanol; H₂O / 70 - 75 °C

3: N-methylmorpholine, 1-HOBt, BOP / dimethylformamide / 0 - 23 °C

With 4-methyl-morpholine; lithium hydroxide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00009-1