vorolanib

Base Information

• Chemical Name: vorolanib
• CAS No.: 1013920-15-4
• Molecular Formula: C₂₃H₂₆FN₅O₃
• Molecular Weight: 439.49
• Mol file: 1013920-15-4.mol

Synonyms:

Chemical Property of vorolanib

Chemical Property:

• Boiling Point: 657.8±55.0 °C(Predicted)
• Density: 1.37±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Vorolanib 99.80% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Vorolanib is an oral anti-VEGFR/PDGFR/CSF1R tyrosine kinase inhibitor that can inhibit angiogenesis in vitro and in vivo.

Technology Process of vorolanib

There total 2 articles about vorolanib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

→ vorolanib (1013920-15-4)

Guidance literature:

Reference yield:

C7H15N3O + 5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (356068-93-4) → vorolanib (1013920-15-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 - 30 ℃; for 22h; Inert atmosphere; Large scale;

upstream raw materials:

5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid