meso-4,6-Bis(2-bromomethyl-3-methyl-5-tert-butylphenyl)-5-methoxy-5-oxo-5H-5λ⁵-phosphole-3,7-diyl diacetate

Base Information

• Chemical Name: meso-4,6-Bis(2-bromomethyl-3-methyl-5-tert-butylphenyl)-5-methoxy-5-oxo-5H-5λ⁵-phosphole-3,7-diyl diacetate
• CAS No.: 112921-26-3
• Molecular Formula: C₄₁H₄₅Br₂O₆P
• Molecular Weight: 824.586
• Mol file: 112921-26-3.mol

Synonyms:

Chemical Property of meso-4,6-Bis(2-bromomethyl-3-methyl-5-tert-butylphenyl)-5-methoxy-5-oxo-5H-5λ⁵-phosphole-3,7-diyl diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of meso-4,6-Bis(2-bromomethyl-3-methyl-5-tert-butylphenyl)-5-methoxy-5-oxo-5H-5λ⁵-phosphole-3,7-diyl diacetate

There total 11 articles about meso-4,6-Bis(2-bromomethyl-3-methyl-5-tert-butylphenyl)-5-methoxy-5-oxo-5H-5λ⁵-phosphole-3,7-diyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3'''-dimethyl-2',2'',4'',6'-tetranitro-5,5'''-t-butylquaterphenyl (111220-58-7) → meso-4,6-Bis(2-bromomethyl-3-methyl-5-tert-butylphenyl)-5-methoxy-5-oxo-5H-5λ5-phosphole-3,7-diyl diacetate (112921-26-3)

Guidance literature:

Multi-step reaction with 10 steps

1: 11.93 g / aluminium chloride / various solvent(s) / 6 h

2: 6.6 percent / hexamethylphosphoric acid triamide / 17 h / 50 °C

3: potassium carbonate / dimethylformamide; methanol; H₂O / 65 h / Heating

4: 1.92 g / Raney nickel/hydrazine hydrate / 2-ethoxy-ethanol / 2 h / 90 °C

5: 1.) sulphuric acid/sodium nitrite, 2.) sulfamic acid, mercury(II) iodide/potassium iodide / 1.) dimethylformamide/water, -5 deg C, 30 min; 2.) dimethylformamide/water, ice cooling, room temp., dimethyl sulphoxide, 125 deg C, 17 h

6: BuLi/phosphorus trichloride / tetrahydrofuran / 2 h

7: 365 mg / water,sodium hydroxide/hydrogen peroxide / tetrahydrofuran / 17 h

8: 360 mg / diethyl ether; CH₂Cl₂

9: 52 mg / boron tribromide / CH₂Cl₂ / 1.) -100 deg C, 15 min; 2.) 0 deg C, 17 h

10: 103 mg / 2,4,6-trimethylpyridine / benzene / 17 h

With 2,4,6-trimethyl-pyridine; sodium hydroxide; n-butyllithium; sulfuric acid; aminosulfonic acid; dihydrogen peroxide; boron tribromide; nickel; potassium carbonate; hydrazine hydrate; potassium iodide; mercury(II) iodide; sodium nitrite; phosphorus trichloride; aluminium trichloride; In tetrahydrofuran; methanol; 2-ethoxy-ethanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; benzene;

Reference yield:

5,5'-di-iodo-1,1'-dimethyl-3,3'-di-t-butyl-10H,10'H-9,9'-dioxa-6,6'-biphenanthrenyl (112945-45-6) → meso-4,6-Bis(2-bromomethyl-3-methyl-5-tert-butylphenyl)-5-methoxy-5-oxo-5H-5λ5-phosphole-3,7-diyl diacetate (112921-26-3)

Guidance literature:

Multi-step reaction with 3 steps

2: BBr₃ / CH₂Cl₂ / 1.) -70 deg C, 50 min; -70 deg C to -20 deg C, 45 min, 2.) ice-cooling, 1 h

3: pyridine / benzene; CHCl₃ / 3 h

With pyridine; boron tribromide; In dichloromethane; chloroform; benzene;

DOI:10.1039/P19960002889

Reference yield:

Methyl 4,13-dimethyl-2,15-di-tert-butyl-17-methoxy-17-oxo-5H,12H,17H-17λ5-phospholo<2,3:3,4;5,4:3',4'>dibenzo<1,2-c:1',2'-c'>bis<2>benzopyran (112921-24-1) → meso-4,6-Bis(2-bromomethyl-3-methyl-5-tert-butylphenyl)-5-methoxy-5-oxo-5H-5λ5-phosphole-3,7-diyl diacetate (112921-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: BBr₃ / CH₂Cl₂ / 1.) -70 deg C, 50 min; -70 deg C to -20 deg C, 45 min, 2.) ice-cooling, 1 h

2: pyridine / benzene; CHCl₃ / 3 h

With pyridine; boron tribromide; In dichloromethane; chloroform; benzene;

DOI:10.1039/P19960002889

upstream raw materials:

acetic anhydride

4,6-bis-(2-bromomethyl-3-methyl-5-t-butylphenyl)-5-methoxydibenzophosphole-3,7-diol 5-oxide

acetyl chloride

5,5'-di-iodo-1,1'-dimethyl-3,3'-di-t-butyl-10H,10'H-9,9'-dioxa-6,6'-biphenanthrenyl

Downstream raw materials:

meso-4,6-Bis(2-dimethoxyphosphorylmethyl-3-methyl-5-tert-butylphenyl)-5-methoxy-5-oxo-5H-5λ⁵-dibenzophosphole-3,7-diyl diacetate

Acetic acid 1-acetoxy-12-tert-butyl-7-[5-tert-butyl-2-(dimethoxy-phosphorylmethyl)-3-methyl-phenyl]-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-6-yl ester

(4-tert-Butyl-2-{6-[5-tert-butyl-2-(dimethoxy-phosphorylmethyl)-3-methyl-phenyl]-3,7-dihydroxy-5-methoxy-5-oxo-5H-5λ⁵-dibenzophosphol-4-yl}-6-methyl-benzyl)-phosphonic acid dimethyl ester

{4-tert-Butyl-2-[6-[5-tert-butyl-2-(dimethoxy-phosphorylmethyl)-3-methyl-phenyl]-3,7-bis-(diethoxy-phosphorylmethoxy)-5-methoxy-5-oxo-5H-5λ⁵-dibenzophosphol-4-yl]-6-methyl-benzyl}-phosphonic acid dimethyl ester