CANDESARTAN-D4

Base Information

• Chemical Name: CANDESARTAN-D4
• CAS No.: 1346604-70-3
• Molecular Formula: C₂₄H₂₀N₆O₃
• Molecular Weight: 444.429
• Mol file: 1346604-70-3.mol

Synonyms:

Chemical Property of CANDESARTAN-D4

Chemical Property:

• Melting Point: 151-157°C
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

98%min ^*data from raw suppliers

Candesartan-d4 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Candesartan-d4 is intended for use as an internal standard for the quantification of candesartan by GC- or LC-MS. Candesartan is an antagonist of the angiotensin II type 1 (AT1) receptor (Kis = 0.17, 0.12, and 0.12 nM for human AT1, rat AT1A, and rat AT1B recombinant receptors, respectively) and an active metabolite of the prodrug candesartan cilexitil (Item No. 10489). It is selective for AT1 over AT2 receptors (Ki = 26,500 nM for the human recombinant AT2 receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID50 = 0.033 mg/kg). Formulations containing candesartan have been used in the treatment of hypertension and heart failure.
• Uses: CANDESARTAN-D4 is an angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive.

Technology Process of CANDESARTAN-D4

There total 9 articles about CANDESARTAN-D4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl)amino)-3-nitrobenzoate (1420880-44-9) → C24H16(2)H4N6O3 (1346604-70-3)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; tin(II) chloride hydrate / 2.5 h / Cooling with ice

2: acetic acid / methanol / 2 h / 80 °C

3: toluene / 25 h / Reflux

4: sodium hydroxide / water; methanol / 1.5 h / Reflux

With hydrogenchloride; tin(II) chloride hydrate; acetic acid; sodium hydroxide; In methanol; water; toluene;

DOI:10.1002/jlcr.2956

Reference yield:

2',3',5',6'-tetra-[2H]-4'-(bromomethyl)biphenyl-2-carbonitrile (1420880-42-7) → C24H16(2)H4N6O3 (1346604-70-3)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium carbonate / acetonitrile / 7 h / Reflux

2: hydrogenchloride / methanol; ethyl acetate / 2 h / 20 °C

3: hydrogenchloride; tin(II) chloride hydrate / 2.5 h / Cooling with ice

4: acetic acid / methanol / 2 h / 80 °C

5: toluene / 25 h / Reflux

6: sodium hydroxide / water; methanol / 1.5 h / Reflux

With hydrogenchloride; tin(II) chloride hydrate; potassium carbonate; acetic acid; sodium hydroxide; In methanol; water; ethyl acetate; toluene; acetonitrile;

DOI:10.1002/jlcr.2956

Reference yield:

ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl)amino)benzoate (1420880-45-0) → C24H16(2)H4N6O3 (1346604-70-3)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / methanol / 2 h / 80 °C

2: toluene / 25 h / Reflux

3: sodium hydroxide / water; methanol / 1.5 h / Reflux

With acetic acid; sodium hydroxide; In methanol; water; toluene;

DOI:10.1002/jlcr.2956

upstream raw materials:

2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-carbonitrile

ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))amino)-3-nitrobenzoate

ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)-3-nitrobenzoate

ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)benzoate

Refernces