(S)-methyl 2-benzyltetrahydrofuran-2-carboxylate

Base Information

Chemical Name:(S)-methyl 2-benzyltetrahydrofuran-2-carboxylate
CAS No.:1637370-37-6
Molecular Formula:C₁₃H₁₆O₃
Molecular Weight:220.268
Hs Code.:

Synonyms:

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Chemical Property of (S)-methyl 2-benzyltetrahydrofuran-2-carboxylate

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Technology Process of (S)-methyl 2-benzyltetrahydrofuran-2-carboxylate

There total 7 articles about (S)-methyl 2-benzyltetrahydrofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20416-11-9
Ethyl 4-oxo-5-phenyl-pentanoate

: 1637370-37-6
(S)-methyl 2-benzyltetrahydrofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 15 h / 0 - 20 °C / Inert atmosphere

2.1: potassium hydroxide / methanol; water / 2 h / 0 - 20 °C / Inert atmosphere

3.1: C₇₀H₆₁O₄PSi₂; iodine; N-chloro-succinimide / toluene / 24 h / -78 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -50 °C / Inert atmosphere

4.2: 0.5 h / 20 °C / Inert atmosphere

5.1: dipyridinium dichromate / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

6.1: toluene; methanol; diethyl ether / 1 h / 20 °C / Inert atmosphere

With N-chloro-succinimide; lithium aluminium tetrahydride; dipyridinium dichromate; C₇₀H₆₁O₄PSi₂; iodine; potassium hydroxide; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201400946

Reference yield:

: 1282061-34-0
4-benzylpent-4-enoic acid

: 1637370-37-6
(S)-methyl 2-benzyltetrahydrofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: C₇₀H₆₁O₄PSi₂; iodine; N-chloro-succinimide / toluene / 24 h / -78 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -50 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: dipyridinium dichromate / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

4.1: toluene; methanol; diethyl ether / 1 h / 20 °C / Inert atmosphere

With N-chloro-succinimide; lithium aluminium tetrahydride; dipyridinium dichromate; C₇₀H₆₁O₄PSi₂; iodine; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201400946

Reference yield:

: 1312844-96-4
ethyl 4-benzylpent-4-enoate

: 1637370-37-6
(S)-methyl 2-benzyltetrahydrofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / methanol; water / 2 h / 0 - 20 °C / Inert atmosphere

2.1: C₇₀H₆₁O₄PSi₂; iodine; N-chloro-succinimide / toluene / 24 h / -78 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -50 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

4.1: dipyridinium dichromate / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

5.1: toluene; methanol; diethyl ether / 1 h / 20 °C / Inert atmosphere

With N-chloro-succinimide; lithium aluminium tetrahydride; dipyridinium dichromate; C₇₀H₆₁O₄PSi₂; iodine; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201400946