C₃₁H₃₅N₂O₉PS

Base Information

• Chemical Name: C₃₁H₃₅N₂O₉PS
• CAS No.: 123201-07-0
• Molecular Formula: C₃₁H₃₅N₂O₉PS
• Molecular Weight: 642.667
• Mol file: 123201-07-0.mol

Synonyms:

Chemical Property of C₃₁H₃₅N₂O₉PS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₁H₃₅N₂O₉PS

There total 10 articles about C₃₁H₃₅N₂O₉PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(2S,3S)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-1-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-isoindole-1,3-dione (123201-02-5,123284-90-2,123284-92-4,123284-93-5) → C31H35N2O9PS (123201-07-0)

Guidance literature:

Multi-step reaction with 5 steps

1: ceric ammonium nitrate, H₂O / acetonitrile / 0 °C

2: 97 percent / n-Bu₄NF, HOAc / tetrahydrofuran / 18 h / 55 °C

3: 97 percent / RuCl₃/NaIO₄ / acetonitrile; H₂O; CCl₄

4: 66 percent / DCC/DMAP / acetonitrile; dimethylformamide

5: 1.) pyridine / 1.) CH₂Cl₂, 0 deg C, 2.) toluene, 90 deg C

With pyridine; dmap; ruthenium trichloride; sodium periodate; ammonium cerium(IV) nitrate; tetrabutyl ammonium fluoride; water; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

N-phthaloylglycine chloride (6780-38-7) → C31H35N2O9PS (123201-07-0)

Guidance literature:

Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂ / 0 °C

2: DBU / benzene / 72 h / 80 °C

3: ceric ammonium nitrate, H₂O / acetonitrile / 0 °C

4: 97 percent / n-Bu₄NF, HOAc / tetrahydrofuran / 18 h / 55 °C

5: 97 percent / RuCl₃/NaIO₄ / acetonitrile; H₂O; CCl₄

6: 66 percent / DCC/DMAP / acetonitrile; dimethylformamide

7: 1.) pyridine / 1.) CH₂Cl₂, 0 deg C, 2.) toluene, 90 deg C

With pyridine; dmap; ruthenium trichloride; sodium periodate; ammonium cerium(IV) nitrate; tetrabutyl ammonium fluoride; water; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;

Reference yield:

(S)-2-[(2S,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-oxo-azetidin-2-yl]-propionic acid (123201-05-8,129029-92-1,129029-93-2,129029-94-3) → C31H35N2O9PS (123201-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / DCC/DMAP / acetonitrile; dimethylformamide

2: 1.) pyridine / 1.) CH₂Cl₂, 0 deg C, 2.) toluene, 90 deg C

With pyridine; dmap; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

allyl oxalyl chloride

(S)-2-[(2R,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-oxo-azetidin-2-yl]-thiopropionic acid S-phenyl ester

triethyl phosphite

(R)-2-[(2S,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-oxo-azetidin-2-yl]-thiopropionic acid S-phenyl ester

Downstream raw materials:

Potassium; (4R,5S,6R)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-7-oxo-3-phenylsulfanyl-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate

Potassium; (4R,5S,6S)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-7-oxo-3-phenylsulfanyl-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate

Potassium; (4S,5S,6S)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-7-oxo-3-phenylsulfanyl-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate

(4S,5S,6S)-6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-7-oxo-3-phenylsulfanyl-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid allyl ester