Technology Process of (S)-2-O-benzyl-3-O-hexadecanoyl-1-O-<6-O-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-gylcero-D-galacto-2-nonulopyranosylonate)-2,3,4-tri-O-acetyl-D-galactopyranosyl>glycerol
There total 9 articles about (S)-2-O-benzyl-3-O-hexadecanoyl-1-O-<6-O-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-gylcero-D-galacto-2-nonulopyranosylonate)-2,3,4-tri-O-acetyl-D-galactopyranosyl>glycerol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
2: H2 / Pd(OH)2-C / methanol / 3 h / Ambient temperature
3: 79.6 percent / pyridine / 15 h / Ambient temperature
4: 65 percent / hydrazine acetate / dimethylformamide; ethyl acetate / 50 °C
5: 1,8-diazabicyclo<5.4.0>undec-7-ene / CH2Cl2 / -5 °C
6: molecular sieves 4A, BF3-Et2O / CH2Cl2 / 1) -10 deg C, 2 h, 2) room temperature, 15 h
With
pyridine; 4 A molecular sieve; boron trifluoride diethyl etherate; hydrogen; hydrazinium monoacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium hydroxide - carbon;
In
methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.3347
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 72.5 percent / pyridine / 3 h / 80 °C
2: 77.4 percent / NH4OH / methanol / 15 h / Ambient temperature
3: 85 percent / triethylamine / CH2Cl2 / 15 h / Ambient temperature
4: 74.6 percent / 80percent AcOH / 1 h / 80 °C
5: molecular sieves 4A, BF3-Et2O / CH2Cl2 / 1) -10 deg C, 2 h, 2) room temperature, 15 h
With
pyridine; ammonium hydroxide; 4 A molecular sieve; boron trifluoride diethyl etherate; acetic acid; triethylamine;
In
methanol; dichloromethane;
DOI:10.1248/cpb.38.3347
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 85 percent / triethylamine / CH2Cl2 / 15 h / Ambient temperature
2: 74.6 percent / 80percent AcOH / 1 h / 80 °C
3: molecular sieves 4A, BF3-Et2O / CH2Cl2 / 1) -10 deg C, 2 h, 2) room temperature, 15 h
With
4 A molecular sieve; boron trifluoride diethyl etherate; acetic acid; triethylamine;
In
dichloromethane;
DOI:10.1248/cpb.38.3347
