(-)-homosalinosporamide A

Base Information

Chemical Name:(-)-homosalinosporamide A
CAS No.:1239987-24-6
Molecular Formula:C₁₆H₂₂ClNO₄
Molecular Weight:327.808
Hs Code.:

Synonyms:

Suppliers and Price of (-)-homosalinosporamide A

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-homosalinosporamide A

Chemical Property:

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Technology Process of (-)-homosalinosporamide A

There total 8 articles about (-)-homosalinosporamide A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239897-16-5
C₂₄H₃₀ClNO₅

: 1239987-24-6
(-)-homosalinosporamide A

Guidance literature:: With ammonium cerium (IV) nitrate; water; In methanol; at 0 ℃; for 6h; Inert atmosphere;
DOI:10.1021/jo101638r

Reference yield:

: 1239897-11-0
C₇H₉ClO₂

: 1239987-24-6
(-)-homosalinosporamide A

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2-hydroxypyridin / 1,2-dichloro-ethane / 53 °C / Microwave irradiation; Inert atmosphere

2.1: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / -5 °C / Inert atmosphere

3.1: 4-pyrrolidin-1-ylpyridine; p-toluenesulfonyl chloride / -5 °C / Inert atmosphere

4.1: palladium on carbon; hydrogen / tetrahydrofuran / 12 h / 23 °C

5.1: dichloro-acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide; toluene / 6 h / 23 °C / Inert atmosphere

6.1: zinc / tetrahydrofuran / 18 h / 23 °C / Inert atmosphere

6.2: 1.5 h / -78 - -20 °C / Inert atmosphere

6.3: Inert atmosphere

7.1: ammonium cerium (IV) nitrate; water / methanol / 6 h / 0 °C / Inert atmosphere

With morpholine; 2-hydroxypyridin; dichloro-acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium cerium (IV) nitrate; palladium on carbon; water; hydrogen; 4-pyrrolidin-1-ylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; p-toluenesulfonyl chloride; zinc; In tetrahydrofuran; methanol; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; 5.1: Moffatt oxidation;
DOI:10.1021/jo101638r

Reference yield:

: 1239897-13-2
C₂₅H₃₀ClNO₆

: 1239987-24-6
(-)-homosalinosporamide A

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-pyrrolidin-1-ylpyridine; p-toluenesulfonyl chloride / -5 °C / Inert atmosphere

2.1: palladium on carbon; hydrogen / tetrahydrofuran / 12 h / 23 °C

3.1: dichloro-acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide; toluene / 6 h / 23 °C / Inert atmosphere

4.1: zinc / tetrahydrofuran / 18 h / 23 °C / Inert atmosphere

4.2: 1.5 h / -78 - -20 °C / Inert atmosphere

4.3: Inert atmosphere

5.1: ammonium cerium (IV) nitrate; water / methanol / 6 h / 0 °C / Inert atmosphere

With dichloro-acetic acid; ammonium cerium (IV) nitrate; palladium on carbon; water; hydrogen; 4-pyrrolidin-1-ylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; p-toluenesulfonyl chloride; zinc; In tetrahydrofuran; methanol; dimethyl sulfoxide; toluene; 3.1: Moffatt oxidation;
DOI:10.1021/jo101638r