2-(5-methyl-6-phenyl-pyridin-2-yl)-pyrido[2,3-d]pyrimidine

Base Information

Chemical Name:2-(5-methyl-6-phenyl-pyridin-2-yl)-pyrido[2,3-d]pyrimidine
CAS No.:1332472-85-1
Molecular Formula:C₁₉H₁₄N₄
Molecular Weight:298.347
Hs Code.:

Synonyms:

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Chemical Property of 2-(5-methyl-6-phenyl-pyridin-2-yl)-pyrido[2,3-d]pyrimidine

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Technology Process of 2-(5-methyl-6-phenyl-pyridin-2-yl)-pyrido[2,3-d]pyrimidine

There total 9 articles about 2-(5-methyl-6-phenyl-pyridin-2-yl)-pyrido[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21038-66-4
1H-Pyrido[2,3-d]pyrimidine-2,4-dione

: 1332472-85-1
2-(5-methyl-6-phenyl-pyridin-2-yl)-pyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diethylaniline; trichlorophosphate / 3 h / Reflux

2: tri-n-butyl-tin hydride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 3 h / 100 °C / Inert atmosphere

3: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 18 h / 100 °C / Sealed vial; Inert atmosphere

With tri-n-butyl-tin hydride; N,N-diethylaniline; lithium chloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 33421-28-2
3-methyl-2-phenylpyridine N-oxide

: 1332472-85-1
2-(5-methyl-6-phenyl-pyridin-2-yl)-pyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic anhydride / 0.75 h / 175 °C / Sealed vial; Microwave irradiation

2.1: phosphorus(V) oxybromide / toluene / 2 h / Reflux

3.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 - 20 °C

4.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 18 h / 100 °C / Sealed vial; Inert atmosphere

With n-butyllithium; acetic anhydride; lithium chloride; phosphorus(V) oxybromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 10273-90-2
2-phenyl-3-methylpyridine

: 1332472-85-1
2-(5-methyl-6-phenyl-pyridin-2-yl)-pyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

2.1: acetic anhydride / 0.75 h / 175 °C / Sealed vial; Microwave irradiation

3.1: phosphorus(V) oxybromide / toluene / 2 h / Reflux

4.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

4.2: 1 h / -78 - 20 °C

5.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 18 h / 100 °C / Sealed vial; Inert atmosphere

With n-butyllithium; acetic anhydride; 3-chloro-benzenecarboperoxoic acid; lithium chloride; phosphorus(V) oxybromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;