4-Oxo-pentanoic acid (2S,3aR,4R,6R,6aS)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3a-hydroxy-6-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b]furan-2-ylmethyl ester

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Chemical Name:4-Oxo-pentanoic acid (2S,3aR,4R,6R,6aS)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3a-hydroxy-6-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b]furan-2-ylmethyl ester
CAS No.:302964-45-0
Molecular Formula:C₃₉H₄₂N₂O₁₁
Molecular Weight:714.769
Hs Code.:

4-Oxo-pentanoic acid (2S,3aR,4R,6R,6aS)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3a-hydroxy-6-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b]furan-2-ylmethyl ester

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Chemical Property of 4-Oxo-pentanoic acid (2S,3aR,4R,6R,6aS)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3a-hydroxy-6-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b]furan-2-ylmethyl ester

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Technology Process of 4-Oxo-pentanoic acid (2S,3aR,4R,6R,6aS)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3a-hydroxy-6-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b]furan-2-ylmethyl ester

There total 4 articles about 4-Oxo-pentanoic acid (2S,3aR,4R,6R,6aS)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3a-hydroxy-6-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b]furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 302964-44-9
4-Oxo-pentanoic acid (2S,3aR,4R,6R,6aS)-3a-hydroxy-4-hydroxymethyl-6-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b]furan-2-ylmethyl ester

: 302964-45-0
4-Oxo-pentanoic acid (2S,3aR,4R,6R,6aS)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3a-hydroxy-6-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b]furan-2-ylmethyl ester

Guidance literature:: With pyridine;
DOI:10.1016/S0960-894X(00)00362-0

Reference yield:

: 40608-06-8
levulinic anhydride

: 302964-45-0
4-Oxo-pentanoic acid (2S,3aR,4R,6R,6aS)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3a-hydroxy-6-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b]furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / 4-(N,N-dimethylamino)pyridine; pyridine

2: 94 percent / H₂ / Pd(OH)2/C / ethanol

3: 90 percent / pyridine

With pyridine; dmap; hydrogen; palladium dihydroxide; In ethanol; 1: Acylation / 2: Debenzylation / 3: tritylation;
DOI:10.1016/S0960-894X(00)00362-0

Reference yield:

: 250222-62-9
(1S,3S,5R,6R,8R)-5-Benzyloxy-6-benzyloxymethyl-3-hydroxymethyl-8-(thymin-1-yl)-2,7-dioxabicyclo[3.3.0]octane

: 302964-45-0
4-Oxo-pentanoic acid (2S,3aR,4R,6R,6aS)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3a-hydroxy-6-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,4-b]furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / 4-(N,N-dimethylamino)pyridine; pyridine

2: 94 percent / H₂ / Pd(OH)2/C / ethanol

3: 90 percent / pyridine

With pyridine; dmap; hydrogen; palladium dihydroxide; In ethanol; 1: Acylation / 2: Debenzylation / 3: tritylation;
DOI:10.1016/S0960-894X(00)00362-0