1-oxacefamandol

Base Information

Chemical Name:1-oxacefamandol
CAS No.:777002-90-1
Molecular Formula:C₁₈H₁₈N₆O₆S
Molecular Weight:446.444
Hs Code.:

Synonyms:

Suppliers and Price of 1-oxacefamandol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-oxacefamandol

Chemical Property:

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Technology Process of 1-oxacefamandol

There total 11 articles about 1-oxacefamandol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67977-91-7,82768-86-3,94480-96-3
diphenylmethyl 7α-benzoylamino-3-methylene-1-oxacepham-4α-carboxylate

: 777002-90-1
1-oxacefamandol

Guidance literature:: Multi-step reaction with 10 steps

1: 1) Cl₂ / 1) CCl₄, 20 min, 0 deg C, 2) CH₂Cl₂-EtOAc, 1-2 h, RT

2: 98 percent / acetone; methanol / 2 h / Heating

3: 1) pyridine, PCl₅, 2) i-BuOH / 1) CH₂Cl₂, 0 deg C, 2 h, 2) 0.5 h, 0 deg C -> 3 h, RT, MeOH, H₂O

4: 5percent NaHCO₃ aq / CH₂Cl₂

6: Huenig base

7: 1) KBH₄, 2) HCl aq

8: 88 percent / NaHSO₃ / ethyl acetate; H₂O / 0.33 h / Ambient temperature

9: 82 percent / m-CPBA / CH₂Cl₂ / 0.5 h / 0 °C

10: trifluoroacetic acid, anisole

With pyridine; hydrogenchloride; potassium borohydride; 2-methyl-propan-1-ol; phosphorus pentachloride; chlorine; sodium hydrogencarbonate; sodium hydrogensulfite; methoxybenzene; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In methanol; dichloromethane; water; ethyl acetate; acetone;
DOI:10.1016/S0040-4020(01)92145-3

Reference yield:

: 83262-19-5
diphenylmethyl 7α-benzoylamino-3β-methylthio-3α-chloromethyl-1-oxacepham-4α-carboxylate

: 777002-90-1
1-oxacefamandol

Guidance literature:: Multi-step reaction with 9 steps

1: 98 percent / acetone; methanol / 2 h / Heating

2: 1) pyridine, PCl₅, 2) i-BuOH / 1) CH₂Cl₂, 0 deg C, 2 h, 2) 0.5 h, 0 deg C -> 3 h, RT, MeOH, H₂O

3: 5percent NaHCO₃ aq / CH₂Cl₂

5: Huenig base

6: 1) KBH₄, 2) HCl aq

7: 88 percent / NaHSO₃ / ethyl acetate; H₂O / 0.33 h / Ambient temperature

8: 82 percent / m-CPBA / CH₂Cl₂ / 0.5 h / 0 °C

9: trifluoroacetic acid, anisole

With pyridine; hydrogenchloride; potassium borohydride; 2-methyl-propan-1-ol; phosphorus pentachloride; sodium hydrogencarbonate; sodium hydrogensulfite; methoxybenzene; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In methanol; dichloromethane; water; ethyl acetate; acetone;
DOI:10.1016/S0040-4020(01)92145-3

Reference yield:

: 83262-30-0
diphenylmethyl 7α-benzoylamino-3β-phenylseleno-3α-chloromethyl-1-oxacepham-4α-carboxylate

: 777002-90-1
1-oxacefamandol

Guidance literature:: Multi-step reaction with 11 steps

1: 80 percent / NaSMTZ

2: 1) Cl₂ / 1) CCl₄, 20 min, 0 deg C, 2) CH₂Cl₂-EtOAc, 1-2 h, RT

3: 98 percent / acetone; methanol / 2 h / Heating

4: 1) pyridine, PCl₅, 2) i-BuOH / 1) CH₂Cl₂, 0 deg C, 2 h, 2) 0.5 h, 0 deg C -> 3 h, RT, MeOH, H₂O

5: 5percent NaHCO₃ aq / CH₂Cl₂

7: Huenig base

8: 1) KBH₄, 2) HCl aq

9: 88 percent / NaHSO₃ / ethyl acetate; H₂O / 0.33 h / Ambient temperature

10: 82 percent / m-CPBA / CH₂Cl₂ / 0.5 h / 0 °C

11: trifluoroacetic acid, anisole

With pyridine; hydrogenchloride; potassium borohydride; 2-methyl-propan-1-ol; phosphorus pentachloride; chlorine; sodium hydrogencarbonate; sodium hydrogensulfite; methoxybenzene; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In methanol; dichloromethane; water; ethyl acetate; acetone;
DOI:10.1016/S0040-4020(01)92145-3