1-isopropyl-6-methoxy-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 1-isopropyl-6-methoxy-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 1344029-45-3
• Molecular Formula: C₂₇H₃₆N₂O₂
• Molecular Weight: 420.595
• Mol file: 1344029-45-3.mol

Synonyms:

Chemical Property of 1-isopropyl-6-methoxy-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-isopropyl-6-methoxy-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about 1-isopropyl-6-methoxy-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(1-isopropyl-6-methoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl]piperidine (1344029-16-8) + phenylacetaldehyde (122-78-1) → 1-isopropyl-6-methoxy-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline (1344029-45-3)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 15h; Cooling with ice;

DOI:10.1248/cpb.59.1029

Reference yield:

1-isopropyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1085538-67-5) → 1-isopropyl-6-methoxy-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline (1344029-45-3)

Guidance literature:

Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 120 h / 20 °C / Cooling with ice

2: hydrogenchloride / ethyl acetate / 24 h / 20 °C / Cooling with ice

3: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 15 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1248/cpb.59.1029

Reference yield:

C24H36N2O4 → 1-isopropyl-6-methoxy-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline (1344029-45-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 24 h / 20 °C / Cooling with ice

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 15 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; ethyl acetate;

DOI:10.1248/cpb.59.1029

upstream raw materials:

1-isopropyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

4-[(1-isopropyl-6-methoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl]piperidine

phenylacetaldehyde

2-(3-methoxyphenyl)-1-ethanamine