(1R,3S,5R)-2-[(R)-2-hydroxy-3-(1-methylcyclopropyl)propionyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide

Base Information

Chemical Name:(1R,3S,5R)-2-[(R)-2-hydroxy-3-(1-methylcyclopropyl)propionyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide
CAS No.:1097133-46-4
Molecular Formula:C₂₁H₂₅ClN₆O₃
Molecular Weight:444.921
Hs Code.:

(1R,3S,5R)-2-[(R)-2-hydroxy-3-(1-methylcyclopropyl)propionyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide

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Chemical Property of (1R,3S,5R)-2-[(R)-2-hydroxy-3-(1-methylcyclopropyl)propionyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide

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Technology Process of (1R,3S,5R)-2-[(R)-2-hydroxy-3-(1-methylcyclopropyl)propionyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide

There total 6 articles about (1R,3S,5R)-2-[(R)-2-hydroxy-3-(1-methylcyclopropyl)propionyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₅ClN₆O

: C₁₀H₁₉ClO₂Si

: 1097133-46-4
(1R,3S,5R)-2-[(R)-2-hydroxy-3-(1-methylcyclopropyl)propionyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide

Guidance literature:: C₁₄H₁₅ClN₆O; C₁₀H₁₉ClO₂Si; With pyridine; In dichloromethane; at 20 ℃;

With methanol;
DOI:10.1039/c5md00479a

Reference yield:

: C₁₉H₂₃ClN₆O₃

: 1097133-46-4
(1R,3S,5R)-2-[(R)-2-hydroxy-3-(1-methylcyclopropyl)propionyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / methanol / 20 °C

2: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; water; In methanol; dichloromethane;
DOI:10.1039/c5md00479a

Reference yield:

: 486394-60-9
2(R)-hydroxy-3-(1-methyl-cyclopropyl)propanoic acid

: 1097133-46-4
(1R,3S,5R)-2-[(R)-2-hydroxy-3-(1-methylcyclopropyl)propionyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; pyridine / 20 °C

1.2: 0 - 20 °C

2.1: pyridine / dichloromethane / 20 °C

With pyridine; dmap; In dichloromethane;
DOI:10.1039/c5md00479a