Technology Process of 1-amino-2-[3,5-diiodo-4-(4'-hydroxy-3'-iodophenoxy)]phenylethylphosphonic acid
There total 10 articles about 1-amino-2-[3,5-diiodo-4-(4'-hydroxy-3'-iodophenoxy)]phenylethylphosphonic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: tetrahydrofuran / 4 h / Heating / reflux
2: hydrogen / palladium 10% on activated carbon / methanol / 16 h
3: [bis(pyridine)iodine]+ tetrafluoroborate / dichloromethane / 1 h / 20 °C
4: pyridine; triethylamine / copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieves 4A
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C
6: water; trifluoroacetic acid / 1 h / 20 °C
7: iodine; methylamine; potassium iodide / ethanol; water / 1 h / 0 °C
8: trimethylsilyl bromide / dichloromethane / 24 h / -78 - 20 °C
With
pyridine; trimethylsilyl bromide; tetrabutyl ammonium fluoride; water; hydrogen; iodine; [bis(pyridine)iodine]+ tetrafluoroborate; triethylamine; methylamine; trifluoroacetic acid; potassium iodide;
palladium 10% on activated carbon; copper diacetate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: sodium tetrahydroborate / nickel dichloride / methanol / 16 h / 20 °C
2: potassium hydroxide; water
3: tetrahydrofuran / 4 h / Heating / reflux
4: hydrogen / palladium 10% on activated carbon / methanol / 16 h
5: [bis(pyridine)iodine]+ tetrafluoroborate / dichloromethane / 1 h / 20 °C
6: pyridine; triethylamine / copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieves 4A
7: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C
8: water; trifluoroacetic acid / 1 h / 20 °C
9: iodine; methylamine; potassium iodide / ethanol; water / 1 h / 0 °C
10: trimethylsilyl bromide / dichloromethane / 24 h / -78 - 20 °C
With
pyridine; potassium hydroxide; sodium tetrahydroborate; trimethylsilyl bromide; tetrabutyl ammonium fluoride; water; hydrogen; iodine; [bis(pyridine)iodine]+ tetrafluoroborate; triethylamine; methylamine; trifluoroacetic acid; potassium iodide;
palladium 10% on activated carbon; copper diacetate; nickel dichloride;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: potassium hydroxide; water
2: tetrahydrofuran / 4 h / Heating / reflux
3: hydrogen / palladium 10% on activated carbon / methanol / 16 h
4: [bis(pyridine)iodine]+ tetrafluoroborate / dichloromethane / 1 h / 20 °C
5: pyridine; triethylamine / copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieves 4A
6: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C
7: water; trifluoroacetic acid / 1 h / 20 °C
8: iodine; methylamine; potassium iodide / ethanol; water / 1 h / 0 °C
9: trimethylsilyl bromide / dichloromethane / 24 h / -78 - 20 °C
With
pyridine; potassium hydroxide; trimethylsilyl bromide; tetrabutyl ammonium fluoride; water; hydrogen; iodine; [bis(pyridine)iodine]+ tetrafluoroborate; triethylamine; methylamine; trifluoroacetic acid; potassium iodide;
palladium 10% on activated carbon; copper diacetate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
