Technology Process of 3-Benzyloxycarbonyl-5-(3-benzyloxypropyl)-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-carbonsaeure
There total 12 articles about 3-Benzyloxycarbonyl-5-(3-benzyloxypropyl)-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-carbonsaeure which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 97 percent / glacial acetic acid / 7 h / Heating
2: 1) aq. NaOH / 1) ethanol, 30 min, reflux, 2) 180 deg C, vacuum
3: 95 percent / LiAlH4 / tetrahydrofuran / 1.5 h / Heating
4: 70 percent / 15 percent K2CO3 / tetrahydrofuran / 3 h / Heating
5: 96 percent / 4-dimethylaminopyridine, pyridine / CH2Cl2 / 2 h / Ambient temperature
6: 91 percent / TBAB, NaI / toluene / 8 h / Heating
7: 5.41 g / NaOH, 31percent H2O2 / ethanol / 5 h / 45 °C
8: 67 percent / AmberlystR 15 / 90 h / 60 °C
9: 0.52 g / KOH / methanol / 8 h / Heating
With
pyridine; dmap; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; AmberlystR 15; tetrabutylammomium bromide; dihydrogen peroxide; potassium carbonate; acetic acid; sodium iodide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)86686-2
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 1) Na / 1) ethanol, 5 deg C, 2) 1.5 h, r.t.
2: 97 percent / glacial acetic acid / 7 h / Heating
3: 1) aq. NaOH / 1) ethanol, 30 min, reflux, 2) 180 deg C, vacuum
4: 95 percent / LiAlH4 / tetrahydrofuran / 1.5 h / Heating
5: 70 percent / 15 percent K2CO3 / tetrahydrofuran / 3 h / Heating
6: 96 percent / 4-dimethylaminopyridine, pyridine / CH2Cl2 / 2 h / Ambient temperature
7: 91 percent / TBAB, NaI / toluene / 8 h / Heating
8: 5.41 g / NaOH, 31percent H2O2 / ethanol / 5 h / 45 °C
9: 67 percent / AmberlystR 15 / 90 h / 60 °C
10: 0.52 g / KOH / methanol / 8 h / Heating
With
pyridine; dmap; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; AmberlystR 15; tetrabutylammomium bromide; dihydrogen peroxide; sodium; potassium carbonate; acetic acid; sodium iodide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)86686-2
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 97 percent / glacial acetic acid / 7 h / Heating
2: 1) aq. NaOH / 1) ethanol, 30 min, reflux, 2) 180 deg C, vacuum
3: 95 percent / LiAlH4 / tetrahydrofuran / 1.5 h / Heating
4: 70 percent / 15 percent K2CO3 / tetrahydrofuran / 3 h / Heating
5: 96 percent / 4-dimethylaminopyridine, pyridine / CH2Cl2 / 2 h / Ambient temperature
6: 91 percent / TBAB, NaI / toluene / 8 h / Heating
7: 5.41 g / NaOH, 31percent H2O2 / ethanol / 5 h / 45 °C
8: 67 percent / AmberlystR 15 / 90 h / 60 °C
9: 0.52 g / KOH / methanol / 8 h / Heating
With
pyridine; dmap; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; AmberlystR 15; tetrabutylammomium bromide; dihydrogen peroxide; potassium carbonate; acetic acid; sodium iodide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)86686-2
