N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-4-{[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl}benzohydrazide trifluoroacetate

Base Information

Chemical Name:N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-4-{[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl}benzohydrazide trifluoroacetate
CAS No.:1055924-93-0
Molecular Formula:C₂HF₃O₂*C₃₀H₄₀N₁₀O
Molecular Weight:670.738
Hs Code.:

N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-4-{[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl}benzohydrazide trifluoroacetate

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Chemical Property of N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-4-{[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl}benzohydrazide trifluoroacetate

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Technology Process of N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-4-{[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl}benzohydrazide trifluoroacetate

There total 11 articles about N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-4-{[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl}benzohydrazide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1055924-92-9
N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-4-{[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl}benzohydrazide

: 76-05-1
trifluoroacetic acid

: 1055924-93-0
N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-4-{[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl}benzohydrazide trifluoroacetate

Guidance literature:: In water; acetonitrile;

Reference yield:

: 1055926-56-1
1,1-dimethylethyl 2-[2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl]-2-cyclopentylhydrazinecarboxylate

: 1055924-93-0
N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-4-{[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl}benzohydrazide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 0.05 h / 150 °C / 9000.9 Torr / Microwave irradiation

2: dowex D-50 (H+) / ethanol / 1 h / Heating / reflux

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C

4: toluene-4-sulfonic acid / acetonitrile / 20 °C

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

7: water; acetonitrile

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 20419-68-5
2,6-dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 1055924-93-0
N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-4-{[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl}benzohydrazide trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 15 h / Heating / reflux

2: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 0.05 h / 150 °C / 9000.9 Torr / Microwave irradiation

3: dowex D-50 (H+) / ethanol / 1 h / Heating / reflux

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C

5: toluene-4-sulfonic acid / acetonitrile / 20 °C

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

7: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

8: water; acetonitrile

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;