4-[(4-fluorobenzyl)oxy]-1-[4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl]pyridin-2(1H)-one

Base Information

• Chemical Name: 4-[(4-fluorobenzyl)oxy]-1-[4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl]pyridin-2(1H)-one
• CAS No.: 1245424-24-1
• Molecular Formula: C₂₃H₂₄FNO₅
• Molecular Weight: 413.446
• Mol file: 1245424-24-1.mol

Synonyms:

Chemical Property of 4-[(4-fluorobenzyl)oxy]-1-[4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl]pyridin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(4-fluorobenzyl)oxy]-1-[4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl]pyridin-2(1H)-one

There total 5 articles about 4-[(4-fluorobenzyl)oxy]-1-[4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl]pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(4-fluorobenzyl)oxy]pyridine-2(1H)-one (586373-38-8) → 4-[(4-fluorobenzyl)oxy]-1-[4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl]pyridin-2(1H)-one (1245424-24-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; N,N`-dimethylethylenediamine / copper(l) iodide / N,N-dimethyl-formamide; 1,4-dioxane / 0.25 h / 180 °C / Microwave irradiation

2: potassium carbonate; monosodium dihydrogen orthophosphate*xH₂O / acetonitrile; water / 4 h / 160 °C / Microwave irradiation

With potassium phosphate; monosodium dihydrogen orthophosphate*xH₂O; potassium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

4-fluorobenzylic alcohol (459-56-3) → 4-[(4-fluorobenzyl)oxy]-1-[4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl]pyridin-2(1H)-one (1245424-24-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 25 °C

1.2: 12 h

2.1: acetic anhydride / 5 h / Reflux

2.2: 3 h / 60 °C

3.1: potassium phosphate; N,N`-dimethylethylenediamine / copper(l) iodide / N,N-dimethyl-formamide; 1,4-dioxane / 0.25 h / 180 °C / Microwave irradiation

4.1: potassium carbonate; monosodium dihydrogen orthophosphate*xH₂O / acetonitrile; water / 4 h / 160 °C / Microwave irradiation

With potassium phosphate; monosodium dihydrogen orthophosphate*xH₂O; acetic anhydride; sodium hydride; potassium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

4-nitraminopyridine N-oxide (1124-33-0) → 4-[(4-fluorobenzyl)oxy]-1-[4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl]pyridin-2(1H)-one (1245424-24-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 25 °C

1.2: 12 h

2.1: acetic anhydride / 5 h / Reflux

2.2: 3 h / 60 °C

3.1: potassium phosphate; N,N`-dimethylethylenediamine / copper(l) iodide / N,N-dimethyl-formamide; 1,4-dioxane / 0.25 h / 180 °C / Microwave irradiation

4.1: potassium carbonate; monosodium dihydrogen orthophosphate*xH₂O / acetonitrile; water / 4 h / 160 °C / Microwave irradiation

With potassium phosphate; monosodium dihydrogen orthophosphate*xH₂O; acetic anhydride; sodium hydride; potassium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

upstream raw materials:

4-fluorobenzylic alcohol

4-nitraminopyridine N-oxide

4-[(4-fluorobenzyl)oxy]pyridine-2(1H)-one

4-[(4-fluorobenzyl)oxy]pyridine 1-oxide