2-bromo-5-methoxy-4-(2,2,2-trifluoroethyl)aniline

Base Information

Chemical Name:2-bromo-5-methoxy-4-(2,2,2-trifluoroethyl)aniline
CAS No.:1257832-57-7
Molecular Formula:C₉H₉BrF₃NO
Molecular Weight:284.076
Hs Code.:

Synonyms:

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Chemical Property of 2-bromo-5-methoxy-4-(2,2,2-trifluoroethyl)aniline

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Technology Process of 2-bromo-5-methoxy-4-(2,2,2-trifluoroethyl)aniline

There total 3 articles about 2-bromo-5-methoxy-4-(2,2,2-trifluoroethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136507-15-8
4-nitro-2-methoxybenzaldehyde

: 1257832-57-7
2-bromo-5-methoxy-4-(2,2,2-trifluoroethyl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: cesium fluoride / 1,2-dimethoxyethane / 1 h / 20 °C / Inert atmosphere; Sonication

1.2: 1 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere; Sonication

2.2: 1.5 h / 50 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 1.5 h / 50 °C / 2844.39 Torr / Inert atmosphere

4.1: bromine; acetic acid / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; bromine; sodium hydride; acetic acid; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; mineral oil;
DOI:10.1021/jm401329s

Reference yield:

: 1257832-51-1
2,2,2-trifluoro-1-(2-methoxy-4-nitrophenyl)ethanol

: 1257832-57-7
2-bromo-5-methoxy-4-(2,2,2-trifluoroethyl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere; Sonication

1.2: 1.5 h / 50 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 1.5 h / 50 °C / 2844.39 Torr / Inert atmosphere

3.1: bromine; acetic acid / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; bromine; sodium hydride; acetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; mineral oil;
DOI:10.1021/jm401329s

Reference yield:

: 1257832-53-3
2,2,2-trifluoro-1-(2-methoxy-4-nitrophenyl)ethyl 4-methylbenzenesulfonate

: 1257832-57-7
2-bromo-5-methoxy-4-(2,2,2-trifluoroethyl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 1.5 h / 50 °C / 2844.39 Torr / Inert atmosphere

2: bromine; acetic acid / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; bromine; acetic acid; In 1,4-dioxane; ethanol;
DOI:10.1021/jm401329s