6-fluoro-PBR₂₈

Base Information

• Chemical Name: 6-fluoro-PBR₂₈
• CAS No.: 1330574-89-4
• Molecular Formula: C₂₁H₁₉FN₂O₃
• Molecular Weight: 366.392
• Mol file: 1330574-89-4.mol

Synonyms:

Chemical Property of 6-fluoro-PBR₂₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-fluoro-PBR₂₈

There total 7 articles about 6-fluoro-PBR₂₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C19H17FN2O2 (1330574-86-1) + acetic anhydride (108-24-7) → 6-fluoro-PBR28 (1330574-89-4)

Guidance literature:

In acetic acid; at 70 ℃;

DOI:10.1016/j.bmcl.2011.06.048

Reference yield:

2-fluoro-5-nitro-4-phenoxypyridine (1330574-80-5) → 6-fluoro-PBR28 (1330574-89-4)

Guidance literature:

Multi-step reaction with 3 steps

1: iron; acetic acid / 20 °C

2: sodium cyanoborohydride; acetic acid / methanol / 20 °C

3: acetic acid / 70 °C

With iron; sodium cyanoborohydride; acetic acid; In methanol; acetic acid;

DOI:10.1016/j.bmcl.2011.06.048

Reference yield:

5-nitro-4-phenoxypyridin-2-ol (1330574-77-0) → 6-fluoro-PBR28 (1330574-89-4)

Guidance literature:

Multi-step reaction with 4 steps

1: diethylamino-sulfur trifluoride / acetonitrile / 75 °C

2: iron; acetic acid / 20 °C

3: sodium cyanoborohydride; acetic acid / methanol / 20 °C

4: acetic acid / 70 °C

With diethylamino-sulfur trifluoride; iron; sodium cyanoborohydride; acetic acid; In methanol; acetic acid; acetonitrile;

DOI:10.1016/j.bmcl.2011.06.048

upstream raw materials:

C₁₉H₁₇FN₂O₂

acetic anhydride

5-nitro-4-phenoxypyridin-2-ol

2-fluoro-5-nitro-4-phenoxypyridine