[(2-{(2-[2-bis(methoxycarbonylmethyl)amino-4-chlorophenoxy]-7-azidooctan-2-yl)oxy}-4-formylphenyl)(methoxycarbonylmethyl)amino]acetic acid methyl ester

Base Information

Chemical Name:[(2-{(2-[2-bis(methoxycarbonylmethyl)amino-4-chlorophenoxy]-7-azidooctan-2-yl)oxy}-4-formylphenyl)(methoxycarbonylmethyl)amino]acetic acid methyl ester
CAS No.:945225-35-4
Molecular Formula:C₃₃H₄₂ClN₅O₁₁
Molecular Weight:720.176
Hs Code.:

[(2-{(2-[2-bis(methoxycarbonylmethyl)amino-4-chlorophenoxy]-7-azidooctan-2-yl)oxy}-4-formylphenyl)(methoxycarbonylmethyl)amino]acetic acid methyl ester

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Chemical Property of [(2-{(2-[2-bis(methoxycarbonylmethyl)amino-4-chlorophenoxy]-7-azidooctan-2-yl)oxy}-4-formylphenyl)(methoxycarbonylmethyl)amino]acetic acid methyl ester

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Technology Process of [(2-{(2-[2-bis(methoxycarbonylmethyl)amino-4-chlorophenoxy]-7-azidooctan-2-yl)oxy}-4-formylphenyl)(methoxycarbonylmethyl)amino]acetic acid methyl ester

There total 9 articles about [(2-{(2-[2-bis(methoxycarbonylmethyl)amino-4-chlorophenoxy]-7-azidooctan-2-yl)oxy}-4-formylphenyl)(methoxycarbonylmethyl)amino]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 945225-34-3
[(2-{(2-[2-bis(methoxycarbonylmethyl)amino-4-chlorophenoxy]-7-bromooctan-2-yl)oxy}-4-formylphenyl)(methoxycarbonylmethyl)amino]acetic acid methyl ester

: 945225-35-4
[(2-{(2-[2-bis(methoxycarbonylmethyl)amino-4-chlorophenoxy]-7-azidooctan-2-yl)oxy}-4-formylphenyl)(methoxycarbonylmethyl)amino]acetic acid methyl ester

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 100 ℃; for 2h;
DOI:10.1021/ja304018d

Reference yield:

: 945225-32-1
[(2-{(2-[2-bis(methoxycarbonylmethyl)amino-4-chlorophenoxy]oct-7-en-2-yl)oxy}phenyl)(methoxycarbonylmethyl)amino]acetic acid methyl ester

: 945225-35-4
[(2-{(2-[2-bis(methoxycarbonylmethyl)amino-4-chlorophenoxy]-7-azidooctan-2-yl)oxy}-4-formylphenyl)(methoxycarbonylmethyl)amino]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate; N,N-dimethyl-formamide / 20.5 h / 20 - 45 °C

2: hydrogen bromide / dichloromethane; acetic acid / 1 h / 20 °C

3: sodium azide / N,N-dimethyl-formamide / 2 h / 100 °C

With sodium azide; hydrogen bromide; N,N-dimethyl-formamide; trichlorophosphate; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ja304018d

Reference yield:

: 89-64-5
p-chloro-o-nitrophenol

: 945225-35-4
[(2-{(2-[2-bis(methoxycarbonylmethyl)amino-4-chlorophenoxy]-7-azidooctan-2-yl)oxy}-4-formylphenyl)(methoxycarbonylmethyl)amino]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: potassium hydroxide / water; dichloromethane

2: N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

3: tin(II) chloride dihdyrate; hydrogenchloride / water; ethanol / 1.5 h / 78 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / Reflux

5: trichlorophosphate; N,N-dimethyl-formamide / 20.5 h / 20 - 45 °C

6: hydrogen bromide / dichloromethane; acetic acid / 1 h / 20 °C

7: sodium azide / N,N-dimethyl-formamide / 2 h / 100 °C

With hydrogenchloride; sodium azide; tin(II) chloride dihdyrate; hydrogen bromide; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; potassium hydroxide; trichlorophosphate; In ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja304018d