Dimethyl <(phenylthio)methyl>malonate

Base Information

Chemical Name:Dimethyl <(phenylthio)methyl>malonate
CAS No.:153180-11-1
Molecular Formula:C₁₆H₂₁NO₅S
Molecular Weight:339.412
Hs Code.:

Dimethyl <N-(isobutyryl)amino><(phenylthio)methyl>malonate

Synonyms:

Suppliers and Price of Dimethyl <(phenylthio)methyl>malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Dimethyl <(phenylthio)methyl>malonate

Chemical Property:

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Technology Process of Dimethyl <(phenylthio)methyl>malonate

There total 1 articles about Dimethyl <(phenylthio)methyl>malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7205-91-6
phenylthiomethyl chloride

: 2-Isobutyrylamino-malonic acid dimethyl ester

: 153180-11-1
Dimethyl <(phenylthio)methyl>malonate

Guidance literature:: With sodium methylate; tetrabutylammomium bromide; In N,N-dimethyl-formamide; Yield given; Ambient temperature;
DOI:10.1021/jo00073a040

Reference yield:

: 153180-11-1
Dimethyl <(phenylthio)methyl>malonate

: 2''-Isopropyl-5-phenylsulfanyl-[2,4';2',4'']teroxazole-4,4-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) NCS, 2.) EtN(i-Pr)2 / 1.) DMF, r.t., 20 min, 2.) 16 h

2: K₂CO₃ / methanol / 1 h / Heating

3: NaOH / methanol / Ambient temperature

4: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

5: Et₃N, DMAP / CH₂Cl₂ / Ambient temperature

6: 1.) NCS, 2.) EtN(i-Pr)2 / 1.) DMF, r.t., 2 h, 2.) 16 h

7: 90 percent / K₂CO₃ / methanol / 4 h / Ambient temperature

8: 96 percent / NaOH / methanol / Ambient temperature

9: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

10: Et₃N, DMAP / CH₂Cl₂ / Ambient temperature

11: 1.) NCS, 2.) EtN(i-Pr)2 / 1.) DMF, r.t., 6 h, 2.) 16 h

With dmap; sodium hydroxide; N-chloro-succinimide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00073a040

Reference yield:

: 153180-11-1
Dimethyl <(phenylthio)methyl>malonate

: 2-(Chloro-phenylsulfanyl-methyl)-2-[(2'-isopropyl-[2,4']bioxazolyl-4-carbonyl)-amino]-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) NCS, 2.) EtN(i-Pr)2 / 1.) DMF, r.t., 20 min, 2.) 16 h

2: K₂CO₃ / methanol / 1 h / Heating

3: NaOH / methanol / Ambient temperature

4: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

5: Et₃N, DMAP / CH₂Cl₂ / Ambient temperature

6: 1.) NCS, 2.) EtN(i-Pr)2 / 1.) DMF, r.t., 2 h, 2.) 16 h

7: 90 percent / K₂CO₃ / methanol / 4 h / Ambient temperature

8: 96 percent / NaOH / methanol / Ambient temperature

9: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

10: Et₃N, DMAP / CH₂Cl₂ / Ambient temperature

11: 1.) NCS, 2.) EtN(i-Pr)2 / 1.) DMF, r.t., 6 h, 2.) 16 h

With dmap; sodium hydroxide; N-chloro-succinimide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00073a040