Technology Process of Methyl <(4-acetoxy-3,5-dimethoxy-2-nitrophenyl)thio>acetate
There total 5 articles about Methyl <(4-acetoxy-3,5-dimethoxy-2-nitrophenyl)thio>acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 62 percent / Br2, NaBr / methanol / 1 h / 0 - 5 °C
2: 99 percent / CH3COONa / 15 h / Ambient temperature
3: 32 percent / 90percent fuming HNO3 / acetic anhydride / 0 deg C to room temp. then room temp., 1 h
4: dithiothreitol / methanol / 24 h / Ambient temperature
5: dimethylformamide / 1 h / 90 - 95 °C
With
bromine; nitric acid; sodium acetate; sodium bromide; diothiothreitol;
In
methanol; acetic anhydride; N,N-dimethyl-formamide;
DOI:10.1021/jo00073a057
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 99 percent / CH3COONa / 15 h / Ambient temperature
2: 32 percent / 90percent fuming HNO3 / acetic anhydride / 0 deg C to room temp. then room temp., 1 h
3: dithiothreitol / methanol / 24 h / Ambient temperature
4: dimethylformamide / 1 h / 90 - 95 °C
With
nitric acid; sodium acetate; diothiothreitol;
In
methanol; acetic anhydride; N,N-dimethyl-formamide;
DOI:10.1021/jo00073a057
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 32 percent / 90percent fuming HNO3 / acetic anhydride / 0 deg C to room temp. then room temp., 1 h
2: dithiothreitol / methanol / 24 h / Ambient temperature
3: dimethylformamide / 1 h / 90 - 95 °C
With
nitric acid; diothiothreitol;
In
methanol; acetic anhydride; N,N-dimethyl-formamide;
DOI:10.1021/jo00073a057
