5,6,7,8-tetrahydronaphthalene-1,4-diyl diacetate

Base Information

• Chemical Name: 5,6,7,8-tetrahydronaphthalene-1,4-diyl diacetate
• CAS No.: 7475-24-3
• Molecular Formula: C₁₄H₁₆O₄
• Molecular Weight: 248.279
• Mol file: 7475-24-3.mol

Synonyms:1,4-Naphthalenediol,5,6,7,8-tetrahydro-, diacetate (6CI,8CI,9CI);1,4-Diacetoxy-5,6,7,8-tetrahydronaphthalene; NSC 401155

Chemical Property of 5,6,7,8-tetrahydronaphthalene-1,4-diyl diacetate

Chemical Property:

• Vapor Pressure: 3.09E-06mmHg at 25°C
• Boiling Point: 388.3°Cat760mmHg
• Flash Point: 195.8°C
• Density: 1.173g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6,7,8-tetrahydronaphthalene-1,4-diyl diacetate

There total 13 articles about 5,6,7,8-tetrahydronaphthalene-1,4-diyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,6,7,8-Tetrahydronaphthalen-1-ol (529-35-1) + acetic anhydride (108-24-7) → 5,6,7,8-tetrahydronaphthalene-1,2-diacetate + 5,6,7,8-tetrahydronaphthalene-1,4-diacetate (7475-24-3)

Guidance literature:

5,6,7,8-Tetrahydronaphthalen-1-ol; In dichloromethane; at 0 - 20 ℃; for 66h;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

acetic anhydride; With pyridine; at 20 ℃; Further stages. Title compound not separated from byproducts.;

DOI:10.1248/cpb.56.239

Reference yield:

1,4-diacetoxynaphthalene (5697-00-7) → 5,6,7,8-tetrahydronaphthalene-1,4-diacetate (7475-24-3)

Guidance literature:

With hydrogenchloride; platinum; gelatine; at 50 - 60 ℃; Hydrogenation;

DOI:10.1111/j.1751-0813.2000.tb11742.x

Reference yield:

[1,4]naphthoquinone (130-15-4) → 5,6,7,8-tetrahydronaphthalene-1,4-diacetate (7475-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: gelatine; aqueous acetic acid; platinum / 50 °C / Hydrogenation

2: sodium acetate

With sodium acetate; acetic acid; platinum; gelatine;

DOI:10.1111/j.1751-0813.2000.tb11742.x

upstream raw materials:

1,4-diacetoxynaphthalene

4-acetyloxy-5,8-dihydronaphthalen-1-yl acetate

8a-acetoxy-6,7,8,8a-tetrahydro-5H-naphthalen-1-one

acetic anhydride

Downstream raw materials:

5,6,7,8-tetrahydronaphthalene-1,4-diol